A NEW METHOD TO SYNTHESIZE FAMCICLOVIR

	A NEW METHOD TO SYNTHESIZE FAMCICLOVIR
	Luo, Lei 1; Chen, Guorong 1; Li, Yuanchao 2
刊名	HETEROCYCLES
	2008-11-01
卷号	75 期号:11 页码:2803-+
关键词	Mitsunobu Reaction Antiviral Drug Synthesis
ISSN号	0385-5414
文献子类	Article
英文摘要	A new and efficient method has been reported for the synthesis of 2-amino-9-[4-acetoxy-3-(acetoxymethyl)butyl-1-yl]purine (famciclovir) starting from guanine. The route involves chlorination of guanine, optimized Mitsunobu reaction, coupling with diethyl malonate, hydrogenation, reduction and esterification, and the overall yield is about 29%. This method does not require any form of chromatographic purification to give pure famciclovir, and it is an industrially viable manufacturing process for this drug.
WOS关键词	PENCICLOVIR ; ANALOGS
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000261352200015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279452]
专题	药物化学研究室
通讯作者	Li, Yuanchao
作者单位	1.E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Luo, Lei,Chen, Guorong,Li, Yuanchao. A NEW METHOD TO SYNTHESIZE FAMCICLOVIR[J]. HETEROCYCLES,2008,75(11):2803-+.
APA	Luo, Lei,Chen, Guorong,&Li, Yuanchao.(2008).A NEW METHOD TO SYNTHESIZE FAMCICLOVIR.HETEROCYCLES,75(11),2803-+.
MLA	Luo, Lei,et al."A NEW METHOD TO SYNTHESIZE FAMCICLOVIR".HETEROCYCLES 75.11(2008):2803-+.