Rh(III)-Catalyzed Intermolecular C-H Amination of 1-Aryl-1H-pyrazol-5(4H)-ones with Alkylamines

doi:10.1021/ol402965d

	Rh(III)-Catalyzed Intermolecular C-H Amination of 1-Aryl-1H-pyrazol-5(4H)-ones with Alkylamines
	Wu, Kui 1,2,3; Fan, Zhoulong 1,2; Xue, Yu 3; Yao, Qizheng 3; Zhang, Ao1,2
刊名	ORGANIC LETTERS
	2014-01-03
卷号	16 期号:1 页码:42-45
ISSN号	1523-7060
DOI	10.1021/ol402965d
文献子类	Article
英文摘要	An intermolecular C-H amination of 1-aryl-1H-pyrazol-5(4H)-ones was achieved under mild reaction conditions, using a low catalyst loading and with a broad scope of aminating reagents. This protocol not only provides the first example of rhodium(III)-catalyzed intermolecular aromatic C H amination directed by an intrinsic functionality of the substrate/product but also features aminating an existing drug with either primary or secondary N-benzoate alkylamines as the coupling partners.
资助项目	Chinese NSF[81125021] ; Chinese NSF[81373277] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica[SIMM1302KF-08]
WOS关键词	CATALYZED ELECTROPHILIC AMINATION ; N BOND FORMATION ; FREE-RADICAL SCAVENGER ; COUPLING REACTIONS ; ROOM-TEMPERATURE ; DIORGANOZINC REAGENTS ; CONVENIENT SYNTHESIS ; NATURAL-PRODUCTS ; AMIDATION ; ACTIVATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000329472800012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277237]
专题	药物化学研究室
通讯作者	Yao, Qizheng
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, Shanghai 200031, Peoples R China 3.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China;
推荐引用方式 GB/T 7714	Wu, Kui,Fan, Zhoulong,Xue, Yu,et al. Rh(III)-Catalyzed Intermolecular C-H Amination of 1-Aryl-1H-pyrazol-5(4H)-ones with Alkylamines[J]. ORGANIC LETTERS,2014,16(1):42-45.
APA	Wu, Kui,Fan, Zhoulong,Xue, Yu,Yao, Qizheng,&Zhang, Ao.(2014).Rh(III)-Catalyzed Intermolecular C-H Amination of 1-Aryl-1H-pyrazol-5(4H)-ones with Alkylamines.ORGANIC LETTERS,16(1),42-45.
MLA	Wu, Kui,et al."Rh(III)-Catalyzed Intermolecular C-H Amination of 1-Aryl-1H-pyrazol-5(4H)-ones with Alkylamines".ORGANIC LETTERS 16.1(2014):42-45.