microRNA-149 targets caspase-2 in glioma progression

doi:10.18632/oncotarget.8506

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	microRNA-149 targets caspase-2 in glioma progression
	Shen, Xiaokun 1; Li, Jie 1; Liao, Wenfeng 1; Wang, Jiwen 2; Chen, Huanjun 1; Yao, Yanli 1; Liu, Houbao 2; Ding, Kan1
刊名	ONCOTARGET
	2016-05-03
卷号	7 期号:18 页码:26388-26399
关键词	glioma microRNA-149 caspase-2 p53
ISSN号	1949-2553
DOI	10.18632/oncotarget.8506
文献子类	Article
英文摘要	Malignant gliomas are the most common form of intrinsic primary brain tumors worldwide. Alterations in microRNAs play a role in highly invasive malignant glioma, but detail mechanism still unknown. In this study, the role and mechanism of microRNA-149 (miR-149) in glioma are investigated. We show that miR-149 is expressed at substantially higher levels in glioma than in normal tissues. Stable overexpression of miR-149 augments potent prosurvival activity, as evidenced by promotion of cell viability, inhibition of apoptosis, and induced xenografted tumor growth in vivo. We further show that Caspase-2 is identified as a functional target of miR-149 and expression of caspase-2 is inversely associated with miR-149 in vitro. In addition, miR-149 promotes tumor survival in the U87-MG and A172 cell lines and it targets caspase-2 via inactivation of the p53 and p21 pathways. There results support a special role for miR-149 by targeting Caspase-2 to impact on p53 signaling pathway. We speculate that miR-149 has distinct biological functions in p53 wild type cells and p53 mutation cells, and the mechanisms involved remain to be explored in future. Our study suggests that targeting miR-149 may be a novel therapy strategy for treating p53 wild type glioma tumors in humans.
资助项目	National Science Foundation for Distinguished Young Scholars of China[81125025] ; National Natural Science Foundation of China[81171914] ; National Natural Science Foundation of China[31230022] ; National Natural Science Foundation of China[81202103] ; National Natural Science Foundation of China[81472714] ; National Natural Science Foundation of China[31370810]
WOS关键词	CENTRAL-NERVOUS-SYSTEM ; INHIBITS PROLIFERATION ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; BREAST-CANCER ; CELLS ; CHEMOTHERAPY ; P53 ; TUMORS ; DEATH
WOS研究方向	Oncology ; Cell Biology
语种	英语
出版者	IMPACT JOURNALS LLC
WOS记录号	WOS:000377722300111
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276044]
专题	药理学第三研究室
通讯作者	Liu, Houbao; Ding, Kan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; 2.Fudan Univ, Gen Surg Inst, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Shen, Xiaokun,Li, Jie,Liao, Wenfeng,et al. microRNA-149 targets caspase-2 in glioma progression[J]. ONCOTARGET,2016,7(18):26388-26399.
APA	Shen, Xiaokun.,Li, Jie.,Liao, Wenfeng.,Wang, Jiwen.,Chen, Huanjun.,...&Ding, Kan.(2016).microRNA-149 targets caspase-2 in glioma progression.ONCOTARGET,7(18),26388-26399.
MLA	Shen, Xiaokun,et al."microRNA-149 targets caspase-2 in glioma progression".ONCOTARGET 7.18(2016):26388-26399.