Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents

doi:10.1021/acs.orglett.6b02755

	Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents
	Peng, Panfeng 1,2; Wang, Jiang1 ; Jiang, Hualiang1,2 ; Liu, Hong1
刊名	ORGANIC LETTERS
	2016-10-21
卷号	18 期号:20 页码:5376-5379
ISSN号	1523-7060
DOI	10.1021/acs.orglett.6b02755
文献子类	Article
英文摘要	In this study we developed a method for the pyridine-directed, rhodium-catalyzed, site-selective C-H alkylation and arylation of pyridones using commercially available trifluoroborate reagents. This simple and versatile transformation proceeded smoothly under relatively mild conditions with perfect site selectivity. The coupling groups in the boron reagents can be extended to primary alkyl, benzyl, and cycloalkyl. Moreover, direct C-H arylation products could also be obtained under similar conditions.
资助项目	National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21602234] ; National Natural Science Foundation of China[81220108025] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304]
WOS关键词	SINGLE-ELECTRON TRANSMETALATION ; C3-SELECTIVE DIRECT ALKYLATION ; ARYL BORONIC ACIDS ; ARYLBORON REAGENTS ; BOND ACTIVATION ; 2-PYRIDONES ; FUNCTIONALIZATION ; HETEROCYCLES ; DERIVATIVES ; CATALYSIS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000386187300048
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275849]
专题	药物化学研究室
通讯作者	Liu, Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wen Hua Rd, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Peng, Panfeng,Wang, Jiang,Jiang, Hualiang,et al. Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents[J]. ORGANIC LETTERS,2016,18(20):5376-5379.
APA	Peng, Panfeng,Wang, Jiang,Jiang, Hualiang,&Liu, Hong.(2016).Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents.ORGANIC LETTERS,18(20),5376-5379.
MLA	Peng, Panfeng,et al."Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents".ORGANIC LETTERS 18.20(2016):5376-5379.