Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides

doi:10.1055/s-0036-1588870

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	Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides
	Tian, Xiaobo 1,2; Yu, Pengqiu 1,2; Tang, Yubo 1; Le, Zhiping 2; Huang, Wei 1,3
刊名	SYNLETT
	2017-09
卷号	28 期号:15 页码:1966-1970
关键词	peptide side-chain ligation side-chain benzyl ester peptide hydrazide arginylglycylaspartic acid peptides branched cyclic peptides
ISSN号	0936-5214
DOI	10.1055/s-0036-1588870
文献子类	Article
英文摘要	Here, we report a peptide aspartic acid side-chain benzyl ester as a useful precursor that can be efficiently converted into various functional groups, including acid, amide, carbonyl hydrazide, carbonyl azide, or thio ester groups, without other protection for the peptide. With this strategy, we synthesized a series of novel branched and cyclic arginylglycylaspartic acid peptides through successive peptide C-terminal ligation and side-chain ligation based on a side-chain carbonyl azide or thio ester.
资助项目	National Natural Science Foundation of China (NNSFC)[21372238] ; National Natural Science Foundation of China (NNSFC)[21572244] ; Personalized Medicines: Molecular Signature-Based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020311]
WOS关键词	HYDRAZIDE LIGATION ; CHEMICAL-SYNTHESIS ; RGD ; ANTAGONISTS ; MIMETICS ; STRATEGY ; ASN
WOS研究方向	Chemistry
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000411346000019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272500]
专题	生物技术药物研发中心（筹）药物安全性评价中心
通讯作者	Le, Zhiping; Huang, Wei
作者单位	1.Chinese Acad Sci, Key Lab Receptor Res, Ctr Excellence Mol Cell Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Dept Chem, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tian, Xiaobo,Yu, Pengqiu,Tang, Yubo,et al. Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides[J]. SYNLETT,2017,28(15):1966-1970.
APA	Tian, Xiaobo,Yu, Pengqiu,Tang, Yubo,Le, Zhiping,&Huang, Wei.(2017).Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides.SYNLETT,28(15),1966-1970.
MLA	Tian, Xiaobo,et al."Aspartic Acid Side-Chain Benzyl Ester as a Multifunctionalization Precursor for Synthesis of Branched and Cyclic Arginylglycylaspartic Acid Peptides".SYNLETT 28.15(2017):1966-1970.