Progress of study on functions and inhibitors of ubiquitin-specific protease 14

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 化学蛋白质组学研究中心

	Progress of study on functions and inhibitors of ubiquitin-specific protease 14
	Jiang Shangwen 2; Liu Bin 1; Tan Minjia2
刊名	Chinese Bulletin of Life Sciences
	2016
卷号	28 期号:11 页码:1377-1383
关键词	USP14 signaling pathway neurologic system cancer inhibitor
ISSN号	1004-0374
其他题名	去泛素化酶USP14的功能及其抑制剂的硏究进展
文献子类	Review
英文摘要	Ubiquitin-specific protease 14 (USP14) is one of the ubiquitin-specific proteases (USP) family of deubiquitinating enzymes (DUBs), which could exert biological effects via trimming ubiquitin from its substrates. USP14 plays an important role in cell signaling transduction, regulation of viral infection, neurological function and carcinogenesis. Many researchers regard USP 14 inhibitor as a novel anti-tumor therapy strategy, because USP 14 is feasible to be a drug target and plays an important role in tumor progression. In this review, we discuss the research advance of USP 14 in signaling pathway, viral infection, nervous system and cancer development, as well as the latest study of USP 14 inhibitors.
资助项目	国家自然科学基金项目[00000000]
WOS研究方向	Cell Biology ; Oncology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5856440
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269228]
专题	化学蛋白质组学研究中心
通讯作者	Tan Minjia
作者单位	1.College of Medicine, Hubei Polytechnic University, Huangshi, Hubei 435000, China. 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式 GB/T 7714	Jiang Shangwen,Liu Bin,Tan Minjia. Progress of study on functions and inhibitors of ubiquitin-specific protease 14[J]. Chinese Bulletin of Life Sciences,2016,28(11):1377-1383.
APA	Jiang Shangwen,Liu Bin,&Tan Minjia.(2016).Progress of study on functions and inhibitors of ubiquitin-specific protease 14.Chinese Bulletin of Life Sciences,28(11),1377-1383.
MLA	Jiang Shangwen,et al."Progress of study on functions and inhibitors of ubiquitin-specific protease 14".Chinese Bulletin of Life Sciences 28.11(2016):1377-1383.