On-resin peptide ligation via C-terminus benzyl ester

doi:10.1016/j.cclet.2018.03.021

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	On-resin peptide ligation via C-terminus benzyl ester
	Zhou, Bin 2,3; Faridoon 1,2; Tian, Xiaobo 2; Li, Jian 1,2; Guan, Dongliang 1,2; Zheng, Xing 3; Guo, Yu 3; Huang, Wei 1,2
刊名	CHINESE CHEMICAL LETTERS
	2018-07
卷号	29 期号:7 页码:1123-1126
关键词	On-resin peptide ligation Peptide benzyl ester Native chemical ligation Auxiliary-assisted peptide ligation Peptide elongation
ISSN号	1001-8417
DOI	10.1016/j.cclet.2018.03.021
文献子类	Article; Proceedings Paper
英文摘要	Here, we report a new approach of on-resin peptide ligation using C-terminal benzyl ester as the stabilized precursor of thioester, which enables both N-terminal elongation and C-terminal peptide ligation on a Rink Amide resin. On-resin native chemical ligation and auxiliary-assisted peptide ligation were successfully achieved. This method is compatible to both protected and unprotected peptide fragments and has potential application in poor water-soluble peptide ligation. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目	Hunan Provincial Innovation Foundation for Postgraduate (China)[CX2017B546] ; National Natural Science Foundation of China[21572244]
WOS关键词	PROTEIN CHEMICAL-SYNTHESIS ; SOLID-PHASE SYNTHESIS ; HYDRAZIDE LIGATION ; CHEMISTRY ; THIOESTERS ; LINKER ; ASN
WOS研究方向	Chemistry
语种	英语
CSCD记录号	CSCD:6275729
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000438004700022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279681]
专题	生物技术药物研发中心（筹）天然药物化学研究室药物安全性评价中心
通讯作者	Faridoon; Guo, Yu; Huang, Wei
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Ctr Excellence Mol Cell Sci, Ctr Biotherapeut Discovery Res,CAS Key Lab Recept, Shanghai 201203, Peoples R China; 3.Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China;
推荐引用方式 GB/T 7714	Zhou, Bin,Faridoon,Tian, Xiaobo,et al. On-resin peptide ligation via C-terminus benzyl ester[J]. CHINESE CHEMICAL LETTERS,2018,29(7):1123-1126.
APA	Zhou, Bin.,Faridoon.,Tian, Xiaobo.,Li, Jian.,Guan, Dongliang.,...&Huang, Wei.(2018).On-resin peptide ligation via C-terminus benzyl ester.CHINESE CHEMICAL LETTERS,29(7),1123-1126.
MLA	Zhou, Bin,et al."On-resin peptide ligation via C-terminus benzyl ester".CHINESE CHEMICAL LETTERS 29.7(2018):1123-1126.