Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells

doi:10.1016/j.fitote.2018.08.006

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells
	Wang, Xiao-Feng 1,3; Li, Heng 1,4; Jiang, Kun 3; Wang, Qi-Qi 1,3; Zheng, Yan-Hai 2; Tang, Wei4 ; Tan, Chang-Heng3
刊名	FITOTERAPIA
	2018-10
卷号	130 页码:61-65
关键词	Perilla frutescens Lamiaceae Monoterpenoid Anti-inflammation RAW264.7 cell
ISSN号	0367-326X
DOI	10.1016/j.fitote.2018.08.006
文献子类	Article
英文摘要	Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. In present study, the low-polarity constituents of the aerial parts of P. frutescens were investigated and their anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were assayed. Three new furanoid monoterpenoids, named as frutescenones A - C (1-3), together with thirteen known compounds (4-16) were isolated and identified on the basis of extensive spectroscopic analysis and a single-crystal X-ray diffraction study. Among these components, 1 is an unusual monoterpenoid with 2,3'-bifuran skeleton, and 3 is a rare perillaketone-adenine hybrid heterodimer, while the revised NMR arrangements of 4 were reported at the first time. Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells.
资助项目	"Personalized Medicines - Molecular Signature -Based Drug Discovery and Development", Strategic Priority Research Program of Chinese Academy of Sciences, China[XDA12040315]
WOS关键词	INHIBITION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000449129500010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279550]
专题	药理学第一研究室天然药物化学研究室
通讯作者	Tang, Wei; Tan, Chang-Heng
作者单位	1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Bot, R&D Ctr Plant Factory, Beijing 100093, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Xiao-Feng,Li, Heng,Jiang, Kun,et al. Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells[J]. FITOTERAPIA,2018,130:61-65.
APA	Wang, Xiao-Feng.,Li, Heng.,Jiang, Kun.,Wang, Qi-Qi.,Zheng, Yan-Hai.,...&Tan, Chang-Heng.(2018).Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells.FITOTERAPIA,130,61-65.
MLA	Wang, Xiao-Feng,et al."Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells".FITOTERAPIA 130(2018):61-65.