Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress

doi:10.1021/jf500387d

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	Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress
	Wang, Ting 2; Sun, Peng 1,2; Chen, Liang 1; Huang, Qi 2; Chen, Kaixian1,2 ; Jia, Qi 1; Li, Yiming 1; Wang, Heyao2
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2014-06-04
卷号	62 期号:22 页码:5038-5045
关键词	cinnamtannin D-1 pancreatic beta-cells apoptosis oxidative stress
ISSN号	0021-8561
DOI	10.1021/jf500387d
文献子类	Article
英文摘要	In previous studies, A-type procyanidin oligomers isolated from Cinnamomum tamala were proved to possess antidiabetic effect and protect pancreatic beta-cells in vivo. The aim of this study was to unveil the mechanisms of protecting pancreatic beta-cells from palmitic acid-induced apoptosis by cinnamtannin D-1 (CD1), one of the main A-type procyanidin oligomers in C. tamala. CD1 was discovered to dose-dependently reduce palmitic acid- or H2O2-induced apoptosis and oxidative stress in INS-1 cells, MIN6 cells, and primary cultured murine islets. Moreover, CD1 could reverse palmitic acid-induced dysfunction of glucose-stimulated insulin secretion in primary cultured islets. These results indicate that reduction of apoptosis and oxidative stress might account for the protection effect of CD1, which provided a better understanding of the mechanisms of the antidiabetic effects of procyanidin oligomers.
资助项目	National Nature Science Foundation of China[81072681] ; National High Technology Research and Development Program of China ("863" Program)[2007AA02Z301] ; State Key Program of Basic Research of China grant ("973" program)[2009CB918502] ; National Science and Technology Major Project[2012ZX09301001-001]
WOS关键词	NITRIC-OXIDE SYNTHASE ; ENDOPLASMIC-RETICULUM STRESS ; BARK EXTRACT PYCNOGENOL(R) ; FATTY-ACID ; MITOCHONDRIAL DYSFUNCTION ; INSULIN-SECRETION ; CINNAMOMUM-CASSIA ; ACINAR-CELLS ; IN-VITRO ; INHIBITION
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000337018700008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277032]
专题	天然药物化学研究室药理学第三研究室
通讯作者	Li, Yiming
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Ting,Sun, Peng,Chen, Liang,et al. Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2014,62(22):5038-5045.
APA	Wang, Ting.,Sun, Peng.,Chen, Liang.,Huang, Qi.,Chen, Kaixian.,...&Wang, Heyao.(2014).Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,62(22),5038-5045.
MLA	Wang, Ting,et al."Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62.22(2014):5038-5045.