INVOLVEMENT OF DORSAL STRIATAL alpha 1-CONTAINING GABA(A) RECEPTORS IN METHAMPHETAMINE-ASSOCIATED REWARDING MEMORIES

doi:10.1016/j.neuroscience.2016.02.001

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	INVOLVEMENT OF DORSAL STRIATAL alpha 1-CONTAINING GABA(A) RECEPTORS IN METHAMPHETAMINE-ASSOCIATED REWARDING MEMORIES
	Jiao, D. -L.2; Liu, Y.2; Long, J. -D.1,3; Du, J.2; Ju, Y. -Y.2; Zan, G. -Y.1,3; Liu, J. -G.1,3; Zhao, M.2
刊名	NEUROSCIENCE
	2016-04-21
卷号	320 页码:230-238
关键词	methamphetamine GABA(A)alpha(1) dorsal striatum rewarding memories conditioned place preference
ISSN号	0306-4522
DOI	10.1016/j.neuroscience.2016.02.001
文献子类	Article
英文摘要	Rewarding memories induced by addictive drugs may contribute to persistent drug-seeking behaviors, which is an important contributing factor to drug addiction. However, the biological mechanisms underlying drug-associated rewarding memories have not yet been fully understood, especially the new synthetic drugs, such as amphetamine-type stimulants (ATS). In this study, using the rat-conditioned place preference (CPP) model, a classic animal model for the reward-associated effects of addictive drugs, we found that the expression level of GABA(A) alpha 1 subunits was significantly decreased in the dorsal striatum (Dstr) after conditioned methamphetamine (METH) pairing, and no significant differences were observed in the other four rewarding memory-associated areas (medial prefrontal cortex (mPFC), nucleus accumbens (NAc), amygdala (Amy), and dorsal hippocampus (DH)). Intra-Dstr injection of either the GABA(A) receptor agonist muscimol or the specific alpha 1GABA(A) receptor-preferring benzodiazepine (BDZ) agonist zolpidem significantly abolished METH CPP formation. Thus, this study extends previous findings by showing that GABA(A) receptors, particularly the alpha 1-containing GABA(A) receptors, may be strongly implicated in METH-associated rewarding memories. This work provides us with a new perspective on the goal of treating ATS addiction. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81271468] ; National Natural Science Foundation of China[U1502228] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] ; Ministry of Education Doctoral Mentor Fund[20120073110089] ; Shanghai Municipal Health and Family Planning Commission joint research project[2014ZYJB0002] ; Ministry of Science and Technology of China[2013CB835100] ; Committee of Science and Technology of Shanghai[13JC140680] ; China Postdoctoral Science Foundation[2014M561482] ; Shanghai Key Laboratory of Psychotic Disorders[13DZ2260500]
WOS关键词	CONDITIONED PLACE PREFERENCE ; RHESUS-MONKEYS ; GABA(A)-RECEPTOR SUBTYPES ; STIMULANT PSYCHOSIS ; COCAINE-SEEKING ; DRUG-ADDICTION ; DOPAMINE ; EXPRESSION ; BRAIN ; REINSTATEMENT
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000371834500022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276071]
专题	药理学第二研究室
通讯作者	Liu, J. -G.; Zhao, M.
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China; 3.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiao, D. -L.,Liu, Y.,Long, J. -D.,et al. INVOLVEMENT OF DORSAL STRIATAL alpha 1-CONTAINING GABA(A) RECEPTORS IN METHAMPHETAMINE-ASSOCIATED REWARDING MEMORIES[J]. NEUROSCIENCE,2016,320:230-238.
APA	Jiao, D. -L..,Liu, Y..,Long, J. -D..,Du, J..,Ju, Y. -Y..,...&Zhao, M..(2016).INVOLVEMENT OF DORSAL STRIATAL alpha 1-CONTAINING GABA(A) RECEPTORS IN METHAMPHETAMINE-ASSOCIATED REWARDING MEMORIES.NEUROSCIENCE,320,230-238.
MLA	Jiao, D. -L.,et al."INVOLVEMENT OF DORSAL STRIATAL alpha 1-CONTAINING GABA(A) RECEPTORS IN METHAMPHETAMINE-ASSOCIATED REWARDING MEMORIES".NEUROSCIENCE 320(2016):230-238.