Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

doi:10.1186/s12868-016-0256-9

	Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia
	Zhang, Tianshu 3; Wang, Wei 1; Huang, Jin 3; Liu, Xia2 ; Zhang, Haiyan1 ; Zhang, Naixia2
刊名	BMC NEUROSCIENCE
	2016-05-20
卷号	17
关键词	Bilateral common carotid arteries occlusion Metabolomics NMR Brain tissue dysfunctions Amino acid metabolism
ISSN号	1471-2202
DOI	10.1186/s12868-016-0256-9
文献子类	Article
英文摘要	Background: To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regional brain tissues of female and male mice upon bilateral common carotid arteries occlusion (BCCAO) operation. Results: Significant metabolic disorders were observed in both cerebral cortex and hippocampus tissues of the experimental mice upon global cerebral ischemic attack. Multiple amino acids were identified as the dominantly perturbed metabolites. It was also shown that although the metabolic profile change patterns in the brain tissues were quite similar in male and female BCCAO mice, metabolic disorders in the cortex tissues were more severe in the female mice than in the male mice. Conclusions: In the present study, significant changes in amino acid metabolic pathways were confirmed in the early stage of global ischemia. Meanwhile, cerebral metabolic dysfunctions were more severe in the female BCCAO mice than in the male mice, suggesting that gender may play a role in different metabolic responses to the ischemic attack, which may provide an important hypothesis for a better understanding of the clinically observed gender-dependent pathological outcome of cerebral ischemia.
资助项目	National Natural Science Foundation of China[21272246] ; National Natural Science Foundation of China[31300608] ; National Natural Science Foundation of China[81173034] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001-004] ; National Key Basic Research Program of China[2013CB910900]
WOS关键词	GAMMA-AMINOBUTYRIC-ACID ; CEREBROSPINAL-FLUID ; ARTERY OCCLUSION ; NMR-SPECTROSCOPY ; AMINO-ACIDS ; RAT ; BIOMARKERS ; TAURINE ; H-1 ; ISCHEMIA/REPERFUSION
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000376498600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276041]
专题	分析化学研究室药理学第二研究室药物安全性评价中心
通讯作者	Liu, Xia; Zhang, Haiyan; Zhang, Naixia
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, Shanghai 201203, Peoples R China; 3.E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Tianshu,Wang, Wei,Huang, Jin,et al. Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia[J]. BMC NEUROSCIENCE,2016,17.
APA	Zhang, Tianshu,Wang, Wei,Huang, Jin,Liu, Xia,Zhang, Haiyan,&Zhang, Naixia.(2016).Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia.BMC NEUROSCIENCE,17.
MLA	Zhang, Tianshu,et al."Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia".BMC NEUROSCIENCE 17(2016).