BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis

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	BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis
	WANG Wei-sheng; JU Yun-yue; WANG Yu-jun; Liu JG(刘景根)
刊名	中国药理学与毒理学杂志
	2017-05-15
卷号	31 期号:05 页码:478
关键词	brain-derived neurotrophic factor memory GABA_A receptor
文献子类	Article
英文摘要	Extinction of aversive memories has been a major concern in neuropsychiatric disorders such as anxiety disorders and drug addiction. The ventromedial prefrontal cortex(vmPFC) is important for memory extinction,but the underlying mechanisms are little known. Here,we report that extinction of conditioned place aversion(CPA),a type of aversive memory associated with drug withdrawal,required activation of Rho GTPase Rac1 in the vmPFC in a brain-derived neurotrophic factor(BDNF)-dependent manner,which triggers actin polymerization via Pak1-cofilin signaling pathway,leading to synaptic localization of activity-regulated cytoskeleton-associated protein(Arc) in the vmPFC. The synaptic Arc further determines GABA_Areceptor(GABA_AR) endocytosis that is necessary and sufficient for vmP FC long-term potentiation and CPA extinction. Thus,extinction of an aversive memory associated with drug withdrawal is intriguingly controlled by Rac1-dependent GABA_AR endocytosis in the vmPFC,thereby suggesting therapeutic targets to promote extinction of the unwanted memory.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269439]
专题	药理学第二研究室
作者单位	中国科学院上海药物研究所,药理学第二研究室,上海 201203, 中国.
推荐引用方式 GB/T 7714	WANG Wei-sheng,JU Yun-yue,WANG Yu-jun,et al. BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis[J]. 中国药理学与毒理学杂志,2017,31(05):478.
APA	WANG Wei-sheng,JU Yun-yue,WANG Yu-jun,&刘景根.(2017).BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis.中国药理学与毒理学杂志,31(05),478.
MLA	WANG Wei-sheng,et al."BDNF dependent Rac1 GTPase activation in the vmPFC contributes to aversive memory extinction by Arc-mediated GABAA receptor endocytosis".中国药理学与毒理学杂志 31.05(2017):478.