EFFECTS OF JITAI ON OPIOID-INDUCED DRUG-SEEKING BEHAVIOR AND RELAPSE | |
Chen Zhongguo1; Chai Jingrui2; Jiang Lihe2; Chen Jie2; Hu Gang1; Liu Jinggen1 | |
刊名 | Chinese Journal of Drug Dependence |
2011 | |
卷号 | 20期号:5页码:346-349 |
关键词 | Jitai drug-seeking behavior relapse self-administration conditioned place preference |
ISSN号 | 1007-9718 |
其他题名 | 济泰片对阿片类物质觅药行为和复吸的治疗作用 |
文献子类 | Article |
英文摘要 | Objective: To study the effects of Jitai,a traditional Chinese medicine,on opioid-induced drug-seeking behavior and relapse.Methods:Models of heroin self-administration in rats and morphine conditioned place preference(CPP) in mice were established and saline or Jitai was administrated through intragastric way to investigate the effects of Jitai on self-administration behavior and reinstatement of CPP.Results:Jitai at the dose of 3.6 g·kg~-1 could inhibit heroin self-administration in rats.Jitai at the dose of 4.3 g·kg~-1could inhibit reinstatement of CPP following a priming injection of morphine in mice.Conclusion:Jitai has the ability to inhibit opioid-induced drug-seeking in animal,and might have a preventive effect on relapse. |
资助项目 | 国家支撑计划[00000000] |
WOS研究方向 | Neurosciences & Neurology (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:4367350 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/267905] |
专题 | 药理学第二研究室 |
通讯作者 | Liu Jinggen |
作者单位 | 1.School of Basic Medical Sciences,Nanjing Medical University, Nanjing, Jiangsu 210029, China.; 2.State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
推荐引用方式 GB/T 7714 | Chen Zhongguo,Chai Jingrui,Jiang Lihe,et al. EFFECTS OF JITAI ON OPIOID-INDUCED DRUG-SEEKING BEHAVIOR AND RELAPSE[J]. Chinese Journal of Drug Dependence,2011,20(5):346-349. |
APA | Chen Zhongguo,Chai Jingrui,Jiang Lihe,Chen Jie,Hu Gang,&Liu Jinggen.(2011).EFFECTS OF JITAI ON OPIOID-INDUCED DRUG-SEEKING BEHAVIOR AND RELAPSE.Chinese Journal of Drug Dependence,20(5),346-349. |
MLA | Chen Zhongguo,et al."EFFECTS OF JITAI ON OPIOID-INDUCED DRUG-SEEKING BEHAVIOR AND RELAPSE".Chinese Journal of Drug Dependence 20.5(2011):346-349. |
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