Application of methyl in drug design

	Application of methyl in drug design
	Lian Jie 2; Wang Jiang1 ; Sun Haifeng 1; Lin Daizong 1; Liu Hong2
刊名	Acta Pharmaceutica Sinica
	2013
卷号	48 期号:8 页码:1195-1208
关键词	methyl drug design lead optimization stereoelectronic effect liposolubility
ISSN号	0513-4870
其他题名	甲基在药物分子设计中的应用
文献子类	Review
英文摘要	The methyl group plays an important role in the rational drug design. Introducing methyl into small molecules has become an important strategy of lead compound optimization. The application of methyl in drug design is reviewed in this paper. Methyl can modulate the physicochemical, pharmacodynamic, and pharmacokinetic properties by ortho effect, inductive effect, and conformational effect. It also improves the metabolic stability as a soft metabolic point. In addition, introducing methyl into drug molecules can also be applied as a strategy in new uses of old drugs and generate me-too drugs.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4908839
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267763]
专题	药物化学研究室
通讯作者	Liu Hong
作者单位	1.State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy,China Pharmaceutical University, State Key Laboratory of Drug Research, Nanjing, Jiangsu 210009, China.;
推荐引用方式 GB/T 7714	Lian Jie,Wang Jiang,Sun Haifeng,et al. Application of methyl in drug design[J]. Acta Pharmaceutica Sinica,2013,48(8):1195-1208.
APA	Lian Jie,Wang Jiang,Sun Haifeng,Lin Daizong,&Liu Hong.(2013).Application of methyl in drug design.Acta Pharmaceutica Sinica,48(8),1195-1208.
MLA	Lian Jie,et al."Application of methyl in drug design".Acta Pharmaceutica Sinica 48.8(2013):1195-1208.