Research progress of anti-influenza virus agents

	Research progress of anti-influenza virus agents
	Zhang, Qiang; Zhao, Qing-jie; Xiong, Rui-sheng; Li, Jian-feng; Shen, Jing-shan
	2010-03
卷号	45
期号	3
页码	289-99
英文摘要	Influenza is a major threat to millions of people worldwide. Vaccines and antiviral agents are two main options available to reduce the impact of the influenza virus, while anti-influenza agents are the most effective means to prevent the transmission of the highly contagious virus and to treat the epidemics of disease. At present, four anti-influenza agents have been approved by the FDA for the treatment of influenza, including two M2 protein ion channel inhibitors-amantadine and rimantadine and two neuraminidase inhibitors-zanamivir and oseltamivir. Arbidol hydrochloride, launched in Russia, is a potent inhibitor of influenza virus, too. Neuraminidase inhibitors could be classified generally by structure into six different kinds: sialic acid derivatives, benzoic acid derivatives, cyclohexene derivatives, cyclopentane derivatives, pyrrolidine derivatives and natural products. In this paper, recent progress in the research of the action mechanisms and structure-activity relationships of these anti-influenza virus agents were reviewed.
会议录	Yao xue xue bao = Acta pharmaceutica Sinica
文献子类	Meeting Abstract;Article;Review
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266933]
专题	药物化学研究室
作者单位	Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Zhang, Qiang,Zhao, Qing-jie,Xiong, Rui-sheng,et al. Research progress of anti-influenza virus agents[C]. 见:.