Pharmaceutical cocrystals of the anti-tuberculosis drug pyrazinamide with dicarboxylic and tricarboxylic acids

doi:10.1039/c4ce02044h

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物质量控制与固体化学研究中心

	Pharmaceutical cocrystals of the anti-tuberculosis drug pyrazinamide with dicarboxylic and tricarboxylic acids
	Wang, Jian-Rong2 ; Ye, Chanjuan 1,2; Zhu, Bingqing 2; Zhou, Chun 2; Mei, Xuefeng2
刊名	CRYSTENGCOMM
	2015
卷号	17 期号:4 页码:747-752
ISSN号	1466-8033
DOI	10.1039/c4ce02044h
文献子类	Article
英文摘要	Four cocrystals of the anti-tuberculosis drug pyrazinamide (PZA) with adipic acid (1), sebacic acid (2), trans-aconitic acid (3), and citric acid (4) were successfully designed and synthesised. Their structures were determined by single-crystal X-ray diffraction, in which 1 and 2 displayed one-dimensional chain structures, while 3 and 4 formed two-dimensional hydrogen-bonded frameworks between PZA and the coformers. The equilibrium solubility and intrinsic dissolution rate (IDR) of the four cocrystals and PZA itself were then determined. The results demonstrate that 3 and 4 exhibit superior solubility and IDR relative to PZA.
资助项目	National Natural Science Foundation of China[81273479] ; National Natural Science Foundation of China[81402898] ; Shanghai Institute of Materia Medica New-Star Plan B for fundin[00000000]
WOS关键词	CO-CRYSTALS ; DESIGN ; PYRAZINECARBOXAMIDE ; DISSOLUTION ; PHASES
WOS研究方向	Chemistry ; Crystallography
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000346897500007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276778]
专题	药物质量控制与固体化学研究中心
通讯作者	Wang, Jian-Rong
作者单位	1.Nanchang Univ, Dept Pharm, Nanchang 330006, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Jian-Rong,Ye, Chanjuan,Zhu, Bingqing,et al. Pharmaceutical cocrystals of the anti-tuberculosis drug pyrazinamide with dicarboxylic and tricarboxylic acids[J]. CRYSTENGCOMM,2015,17(4):747-752.
APA	Wang, Jian-Rong,Ye, Chanjuan,Zhu, Bingqing,Zhou, Chun,&Mei, Xuefeng.(2015).Pharmaceutical cocrystals of the anti-tuberculosis drug pyrazinamide with dicarboxylic and tricarboxylic acids.CRYSTENGCOMM,17(4),747-752.
MLA	Wang, Jian-Rong,et al."Pharmaceutical cocrystals of the anti-tuberculosis drug pyrazinamide with dicarboxylic and tricarboxylic acids".CRYSTENGCOMM 17.4(2015):747-752.