Study on structure-activity relationship of eleven natural flavonoids scavenging superoxide anion

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Study on structure-activity relationship of eleven natural flavonoids scavenging superoxide anion
	Chen Jiwu 1; Hu Tianxi 1; Zhu Dayuan 2
刊名	Chinese Pharmaceutical Journal
	2002
卷号	37 期号:1 页码:57-58
关键词	flavonoids superoxide anion structure-activity relationship
ISSN号	1001-2494
其他题名	11种黄酮类化合物清除超氧阴离子的构效关系研究
文献子类	Article
英文摘要	OBJECTIVE The structure-activity relationship of eleven pure and natural flavonoids scavenging superoxide anion (O_2~-) were studied so as to find some regularities, which may provide the foundation for their further exploitation and utility. METHODS The sensitive chemiluminescence system was used. RESULTS Nine natural flavonoids effectively scavenged O_2~-. The ability of scavenging O_2~- in turn was:baicalin>heliosin>quercetin>rutin>hyperoside>kaempferol>licochalcone> hesperidin>nevadensin,whereas nobilitin and corylifolin-Ac did not scavenge O_2~-. CONCLUSION ①Hydroxyl groups in the A ring and/or B ring were main　active groups scavenging O_2~-. ②A ring and/or B ring with adjacent hydroxyl groups greatly increased their ability of scavenging O_2~-. ③The hydroxyl group in the 6 position on the A ring and the hydroxyl groups in 3、4position on the B ring possessed the high activity of scavenging O_2~-. ④The glucoside contributed to scavenge O_2~-, which varied with sort of the glucoside. ⑤The phenolic hydroxyl compounds usually have activity scavenging O_2~-.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:1110629
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268485]
专题	天然药物化学研究室
作者单位	1.School of Life Science, East China Normal University, Shanghai 200062, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
推荐引用方式 GB/T 7714	Chen Jiwu,Hu Tianxi,Zhu Dayuan. Study on structure-activity relationship of eleven natural flavonoids scavenging superoxide anion[J]. Chinese Pharmaceutical Journal,2002,37(1):57-58.
APA	Chen Jiwu,Hu Tianxi,&Zhu Dayuan.(2002).Study on structure-activity relationship of eleven natural flavonoids scavenging superoxide anion.Chinese Pharmaceutical Journal,37(1),57-58.
MLA	Chen Jiwu,et al."Study on structure-activity relationship of eleven natural flavonoids scavenging superoxide anion".Chinese Pharmaceutical Journal 37.1(2002):57-58.