Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection
	PAN Feng 1; CHEN Qing-hua 1; BAO Yong-chu 1; ZHU Da-yuan 2; JIANG Shan-hao 2
刊名	Chinese Journal of Pharmaceuticals
	2009
卷号	40 期号:6 页码:421-424
关键词	huperzine A microsphere burst effect o/w emulsion in-liquid drying process o/o emulsion in-liquid drying process
ISSN号	1001-8255
其他题名	石杉碱甲注射用缓释微球制备方法的比较及其体内外评价
文献子类	Article
英文摘要	The biodegradable sustained-release microspheres loaded with huperzine A for injection were prepared by o/w and o/o emulsion in-liquid drying process,respectively.The physicochemical properties of huperzine A-PLGA microspheres prepared by two methods were comparatively studied in terms of the morphology,particle size and the distribution,as well as the in vivo and in vitro drug release behavior.The results showed that the method of o/o emulsion in-liquid drying process had the advantage in preparing of injectable huperzine A microspheres.
资助项目	上海市科蚕2002年重点科研项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:3543312
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267977]
专题	天然药物化学研究室
作者单位	1.Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China.; 2.Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	PAN Feng,CHEN Qing-hua,BAO Yong-chu,et al. Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection[J]. Chinese Journal of Pharmaceuticals,2009,40(6):421-424.
APA	PAN Feng,CHEN Qing-hua,BAO Yong-chu,ZHU Da-yuan,&JIANG Shan-hao.(2009).Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection.Chinese Journal of Pharmaceuticals,40(6),421-424.
MLA	PAN Feng,et al."Comparative Study on Preparation and in vitro/in vivo Release Behavior of Huperzine A Biodegradable Sustained-release Microspheres for Injection".Chinese Journal of Pharmaceuticals 40.6(2009):421-424.