Dimeric Sesquiterpenoids

doi:10.1007/978-3-319-22692-7_1

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Dimeric Sesquiterpenoids
	Liao, Shang-Gao; Yue, Jian-Min
刊名	Progress in the chemistry of organic natural products
	2016
卷号	101 页码:1-112
ISSN号	2191-7043
DOI	10.1007/978-3-319-22692-7_1
文献子类	Article;Review
英文摘要	It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents. As dimeric molecules might be able to act on both moieties of a dimeric protein, dimeric sesquiterpenoids (DSs), which are generated biogenetically from coupling of two sesquiterpenoid molecules, are in essence potential biologically active molecules, and have attracted in recent years great attention for their peculiar structures and biological activities. In fact, a number of DSs are more potent than their monomeric precursors for some activities such as anti-inflammatory, anti-tumor, immunosuppressive, potassium channel blocking, antimalarial, anti-virus, and neurotrophic activities.The complex and diversified structures of DSs also attracted attention of chemists in their isolation, structural elucidation, and synthetic construction.In the contribution, a general view of the classification and distribution of DSs will be provided. Strategies for the structural elucidation of DSs and their analogues is presented. Chemical strategies for the convergence of the two sesquiterpenoid units is reviewed. Biological activities are discussed under each type of activity.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266781]
专题	天然药物化学研究室
通讯作者	Liao, Shang-Gao; Yue, Jian-Min
作者单位	School of Pharmacy, Guizhou Medical University, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China
推荐引用方式 GB/T 7714	Liao, Shang-Gao,Yue, Jian-Min. Dimeric Sesquiterpenoids[J]. Progress in the chemistry of organic natural products,2016,101:1-112.
APA	Liao, Shang-Gao,&Yue, Jian-Min.(2016).Dimeric Sesquiterpenoids.Progress in the chemistry of organic natural products,101,1-112.
MLA	Liao, Shang-Gao,et al."Dimeric Sesquiterpenoids".Progress in the chemistry of organic natural products 101(2016):1-112.