Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities

doi:10.1016/j.phytochem.2017.12.002

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	Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities
	Wang, Wen-qiong; Yin, Yan-peng; Jun, Li; Xuan, Li-jiang
刊名	PHYTOCHEMISTRY
	2018-02
卷号	146 页码:56-62
关键词	Vitex rotundifolia (verbenaceae) Diterpenoids Anti-hyperlipidemia
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2017.12.002
文献子类	Article
英文摘要	Vitex rotundifolia is the variant of the traditional Chinese medicine (TCM) Vitex trifolia. Diterpenoids from V trifolia have shown anti-hyperlipidemia activity. As part of a continuous research program of searching for anti-hyperlipidemia constituents from TCM, 95% alcohol extract of the fruits of V rotundifolia was fully studied, and 18 diterpenoids were isolated, including eight previously undescribed compounds (viterofolins A-H). Among them, viterofolins A-B were previously undescribed rearranged halimane-type diterpenoids, viterofolins C-H were previously undescribed halimane-type diterpenoids. These compounds were then firstly evaluated in lipid (Dil-LDL) uptake assay in HepG2 cells. Viterofolin H, (5S, GR, 8R, 9R, 10S)-6-acetoxy-9-hydroxy-13 (14)-labden-16,15-olide and previtexilactone showed moderate activities in promoting LDL uptake (1.27-1.35 fold). This work laid the foundation for searching antihyperlipidemia natural products. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[81473111] ; National Natural Science Foundation of China[21702219] ; China Postdoctoral Science Foundation[2016M600345]
WOS关键词	GENE-EXPRESSION ; CONSTITUENTS ; FRUIT ; CELLS ; LDL
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000423895200007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279934]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xuan, Li-jiang
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wen-qiong,Yin, Yan-peng,Jun, Li,et al. Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities[J]. PHYTOCHEMISTRY,2018,146:56-62.
APA	Wang, Wen-qiong,Yin, Yan-peng,Jun, Li,&Xuan, Li-jiang.(2018).Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities.PHYTOCHEMISTRY,146,56-62.
MLA	Wang, Wen-qiong,et al."Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities".PHYTOCHEMISTRY 146(2018):56-62.