Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes

doi:10.1016/j.bmcl.2017.12.045

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes
	Qin, Jun-Jun 3,4; Lin, Ze-Min 5; Xu, Yan-Sheng 5; Ren, Ji-Wen 1; Zuo, Jian-Ping2 ; Zhao, Wei-Min3
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2018-02-01
卷号	28 期号:3 页码:330-333
关键词	Spiroorthoester group Pregnane glycosides Periploca chrysantha Immunosuppression
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2017.12.045
文献子类	Article
英文摘要	Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides (1-4), named periplosides W-Y and 3-O-formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides (1-4) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	Science and Technology Commission of Shanghai Municipality[15401901200] ; National Natural Science Foundation[81273399]
WOS关键词	CHEMICAL-CONSTITUENTS ; ANTITUMOR FRACTION ; SEPIUM BGE ; IMMUNOSUPPRESSION ; ENCEPHALOMYELITIS ; CELLS ; MICE
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000424285600019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279930]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Zuo, Jian-Ping; Zhao, Wei-Min
作者单位	1.Gansu Forestry Technol Coll, 58 Mapaoquan Rd, Tianshui 741020, Gansu, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 5.Shanghai Univ Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201210, Peoples R China;
推荐引用方式 GB/T 7714	Qin, Jun-Jun,Lin, Ze-Min,Xu, Yan-Sheng,et al. Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(3):330-333.
APA	Qin, Jun-Jun,Lin, Ze-Min,Xu, Yan-Sheng,Ren, Ji-Wen,Zuo, Jian-Ping,&Zhao, Wei-Min.(2018).Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(3),330-333.
MLA	Qin, Jun-Jun,et al."Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.3(2018):330-333.