Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis

doi:10.1002/adfm.201705622

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis
	He, Bin 1,2,4; Tan, Tao 1,3,4; Wang, Hong 1,4; Hu, Haiyan 2; Wang, Zhiwan 1,4; Wang, Jing 2; Li, Jie 1,4; Sun, Kaoxiang 2; Zhang, Zhiwen1,4 ; Li, Yaping1,2,4
刊名	ADVANCED FUNCTIONAL MATERIALS
	2018-02-21
卷号	28 期号:8
关键词	cabazitaxel cancer metastasis micelles programed targeting tumor microenvironment
ISSN号	1616-301X
DOI	10.1002/adfm.201705622
文献子类	Article
英文摘要	The poor drug delivery to primary and metastatic tumors of breast cancer remains a great challenge for effective antimetastasis therapy. Herein, a tumor microenvironment-activated cabazitaxel micelles decorated with legumain-specific melittin (TCM-legM) are rationally designed for programed targeting of breast cancer metastasis. TCM-legM is quiescent in blood circulation, but can be specifically activated by the highly expressed legumain in tumor microenvironments to improve their specific targeting and deep penetrating to primary or metastatic tumors. Thereafter, the activated TCM-legM can be efficiently internalized by cancer cells and motivate the rapid pH-responsive drug release for antimetastasis therapy. In metastatic 4T1 breast cancer cells, TCM-legM presents significant inhibition on the proliferation, migration, and invasion activities. In vivo, TCM-legM can be effectively delivered to both primary and metastatic tumors of breast cancer with deep tumor penetration and efficient cellular internalization, thereby resulting in a notable reduction of tumor growth and producing a 93.4% suppression of lung metastasis. Taken together, the rationally designed TCM-legM can provide an intelligent drug delivery strategy to enhance the medical performance on treating breast cancer metastasis.
资助项目	National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of CAS[00000000]
WOS关键词	LUNG METASTASIS ; IN-VIVO ; DRUG-DELIVERY ; CELLULAR INTERNALIZATION ; POLYMERIC MICELLES ; WORMLIKE MICELLES ; SIRNA DELIVERY ; PENETRATION ; THERAPY ; SIZE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000425448200022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279894]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Medica, State key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Medica, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	He, Bin,Tan, Tao,Wang, Hong,et al. Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(8).
APA	He, Bin.,Tan, Tao.,Wang, Hong.,Hu, Haiyan.,Wang, Zhiwan.,...&Li, Yaping.(2018).Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis.ADVANCED FUNCTIONAL MATERIALS,28(8).
MLA	He, Bin,et al."Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis".ADVANCED FUNCTIONAL MATERIALS 28.8(2018).