A novel photocleavable heparin derivative with light controllable anticoagulant activity | |
Sun, Feifei1,2; Liu, Yinyin1; Wang, Dongdong1; Wang, Zhaojie1; Mu, Haibo1; Wang, Feng1; Ding, Kan2; Duan, Jinyou1 | |
刊名 | CARBOHYDRATE POLYMERS |
2018-03-15 | |
卷号 | 184页码:191-198 |
关键词 | Glycosaminoglycan Heparin Photocaging Anticoagulant |
ISSN号 | 0144-8617 |
DOI | 10.1016/j.carbpol.2017.12.057 |
文献子类 | Article |
英文摘要 | Heparin (HP) has enormous potential for clinical medication applications owing to its anticoagulant activity. However, the strong anticoagulant capacity of HP also leads to some side effects. Herein, a photocaged derivative (HP-DMNB) of HP was synthesized for light control of its anticoagulant activity. The synthesized HP-DMNB was characterized by NMR and FTIR analysis, which confirmed the successful modification of HP with the photocleavable 4,5-dimethoxyl-2-nitrobenzyl (DMNB) groups. After the modification, the molecular weight of HP-DMNB (DS = 0.34%) changed from 61 to 71 kDa. Anticoagulant activity analysis showed that HP-DMNB had a reduced anticoagulant capacity compared with commercial HP, while its anticoagulant activity will regain after releasing the free carboxyl groups of HP under UV light. In addition, HP-DMNB and its UV irradiated products were observed to possess good biocompatibility through the MTT assays and live-dead assays with HaCaT cells, which may have impacts on the clinical medication applications of HP. |
资助项目 | National Natural Science Foundation of China (NSFC)[31570799] ; Fundamental Research Funds for the Central Universities, Northwest AF University[2452017026] ; Fundamental Research Funds for the Central Universities, Northwest AF University[Z109021713] ; State Key Laboratory of Drug Research[SIMM1705KF-16] |
WOS关键词 | ACTINIDIA-CHINENSIS ROOTS ; ANTITHROMBOTIC ACTIVITIES ; CANCER-THERAPY ; FACTOR-XII ; POLYSACCHARIDES ; DELIVERY ; RELEASE ; KERATINOCYTES ; COAGULATION ; ANTIOXIDANT |
WOS研究方向 | Chemistry ; Polymer Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000423720500022 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/279851] |
专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
通讯作者 | Duan, Jinyou |
作者单位 | 1.Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Feifei,Liu, Yinyin,Wang, Dongdong,et al. A novel photocleavable heparin derivative with light controllable anticoagulant activity[J]. CARBOHYDRATE POLYMERS,2018,184:191-198. |
APA | Sun, Feifei.,Liu, Yinyin.,Wang, Dongdong.,Wang, Zhaojie.,Mu, Haibo.,...&Duan, Jinyou.(2018).A novel photocleavable heparin derivative with light controllable anticoagulant activity.CARBOHYDRATE POLYMERS,184,191-198. |
MLA | Sun, Feifei,et al."A novel photocleavable heparin derivative with light controllable anticoagulant activity".CARBOHYDRATE POLYMERS 184(2018):191-198. |
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