Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression

doi:10.1016/j.bmcl.2018.02.010

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression
	Zhou, Zhen-Fang 2; Li, Xiao-Lu 2; Yao, Li-Gong 2; Li, Jia2 ; Gavagnin, Margherita 1; Guo, Yue-Wei2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2018-04-01
卷号	28 期号:6 页码:1093-1096
关键词	Pulmonate Polypropionates Absolute configuration XBP1
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2018.02.010
文献子类	Article
英文摘要	Two additional new members of the onchidione family, 16-epi-onchidione (1) and 4-epi-onchidione (2), co-occurring with six previously reported bis-gamma-pyrone polypropionates including onchidione (3), were isolated from the marine pulmonate Onchidium sp. Their structures were determined by extensive spectroscopic analysis and by comparison with 3 and onchidione-related derivatives. The absolute configuration of 1 was established by X-ray diffraction analysis employing graphite monochromated Cu K-alpha radiation (lambda = 0.71073 angstrom) with small Flack parameter 0.08. In addition, the absolute stereochemistry of previously reported onchidionol (6) was confirmed by the X-ray diffraction analysis. Some of the isolated compounds showed significant activation effects on the splicing of XBP1 mRNA as ER stress modulators to inhibit the growth of tumors. (C) 2018 Elsevier Ltd. All rights reserved.
资助项目	Natural Science Foundation of China (NSFC) key international collaboration project[81520108028] ; NSFC[21672230] ; NSFC[41676073] ; NSFC[81473244] ; NSFC-Shandong Joint Fundfor Marine Science Research Centers[U1606403] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM 1705ZZ-01] ; MIUR-ITALY PRIN[2015MSCKCE_003]
WOS关键词	NATURAL-PRODUCTS ; ILIKONAPYRONE ; CHEMISTRY ; ESTERS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000427531500020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279834]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Gavagnin, Margherita; Guo, Yue-Wei
作者单位	1.CNR, ICB, Via Campi Flegrei 34, I-80078 Naples, Italy 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Zuchongzhi Rd 555 Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhou, Zhen-Fang,Li, Xiao-Lu,Yao, Li-Gong,et al. Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(6):1093-1096.
APA	Zhou, Zhen-Fang,Li, Xiao-Lu,Yao, Li-Gong,Li, Jia,Gavagnin, Margherita,&Guo, Yue-Wei.(2018).Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(6),1093-1096.
MLA	Zhou, Zhen-Fang,et al."Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.6(2018):1093-1096.