Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis

doi:10.1021/acs.nanolett.8b01236

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	Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis
	Cao, Haiqiang 1,2,3; Wang, Hong 1,2,3; He, Xinyu 1,2,3; Tan, Tao 2,3; Hu, Haiyan 2,3; Wang, Zhiwan 1,2,3; Wang, Jing 2,3; Li, Jie 2,3; Zhang, Zhiwen2,3 ; Li, Yaping2,3,4
刊名	NANO LETTERS
	2018-08
卷号	18 期号:8 页码:4762-4770
关键词	Macrophage drug delivery cancer metastasis nanovesicles
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.8b01236
文献子类	Article
英文摘要	Specific drug delivery to metastatic tumors remains a great challenge for antimetastasis therapy. We herein report a bioengineered macrophage-based delivery system (LD-MDS) that can be preferentially delivered to lung metastases and intelligently transformed into nanovesicles and secondary nanovesicles for antimetastasis therapy. LD-MDS was prepared by anchoring a legumain-specific propeptide of melittin (legM) and cytotoxic soravtansine (DM4) prodrug onto the membrane of living macrophages. LD-MDS is responsively activated by legumain protease and converted into DM4-loaded exosome-like nanovesicles (DENs), facilitating efficient internalization by metastatic 4T1 cancer cells and considerable cell death. Afterward, the damaged 4T1 cells can release secondary nanovesicles and free drug molecules to destroy neighboring cancer cells. In vivo, LD-MDS displays superior targeting efficiency for lung metastatic lesions with diameters less than 100 mu m and remarkably inhibits lung metastasis. This study provides a new opportunity to explore endogenous macrophages as living drug delivery vehicles with controlled drug release to target metastatic lung tumors.
资助项目	National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of CAS[00000000] ; Shanghai Sailing Program[18YF1428400]
WOS关键词	MESENCHYMAL STEM-CELLS ; TUMOR-ASSOCIATED MACROPHAGES ; DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; BREAST-CANCER ; NANOPARTICLES ; MEMBRANE ; NANOCARRIERS ; DESIGN ; PROBE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000441478300020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279636]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Cao, Haiqiang,Wang, Hong,He, Xinyu,et al. Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis[J]. NANO LETTERS,2018,18(8):4762-4770.
APA	Cao, Haiqiang.,Wang, Hong.,He, Xinyu.,Tan, Tao.,Hu, Haiyan.,...&Li, Yaping.(2018).Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis.NANO LETTERS,18(8),4762-4770.
MLA	Cao, Haiqiang,et al."Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis".NANO LETTERS 18.8(2018):4762-4770.