Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale

doi:10.1021/acs.orglett.8b02340

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	Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale
	Fan, Yao-Yue; Sun, Yi-Li; Zhou, Bin; Zhao, Jin-Xin; Sheng, Li; Li, Jing-Ya; Yue, Jian-Min
刊名	ORGANIC LETTERS
	2018-09-07
卷号	20 期号:17 页码:5435-5438
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b02340
文献子类	Article
英文摘要	Hedyorienoids A (1) and B (2), two sesquiterpenoid dimers, were isolated and characterized from Hedyosmum orientale. Compound 1 was an unprecedented heterodimer of two different classes of sesquiterpenoids furnished by forming an unusual 1,3-dioxolane ring, while compound 2 possessed a new dimerization pattern of two guaiane-type sesquiterpenoids. Biosynthetic pathways for 1 and 2 were proposed with the coexisting monomers chloranthalactone A (3) and hedyosumin A (4) as the precursors. Compounds 2 and 3 showed significant NF-kappa B inhibitory activity.
资助项目	National Natural Science Foundation of the P. R China[21532007] ; National Natural Science Foundation of the P. R China[21772213] ; National Natural Science Foundation of the P. R China[21772212] ; National Natural Science Foundation of the P. R China[81673493]
WOS关键词	NF-KAPPA-B ; BIOMIMETIC SYNTHESES ; A-C ; CANCER ; PLANTS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000444527000081
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279584]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Li, Jing-Ya; Yue, Jian-Min
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Fan, Yao-Yue,Sun, Yi-Li,Zhou, Bin,et al. Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale[J]. ORGANIC LETTERS,2018,20(17):5435-5438.
APA	Fan, Yao-Yue.,Sun, Yi-Li.,Zhou, Bin.,Zhao, Jin-Xin.,Sheng, Li.,...&Yue, Jian-Min.(2018).Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale.ORGANIC LETTERS,20(17),5435-5438.
MLA	Fan, Yao-Yue,et al."Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale".ORGANIC LETTERS 20.17(2018):5435-5438.