Three New Cytotoxic Monoterpenoid Bisindole Alkaloids from Tabernaemontana bufalina

doi:10.1055/a-0608-4988

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	Three New Cytotoxic Monoterpenoid Bisindole Alkaloids from Tabernaemontana bufalina
	Zhou, Si-Yuan 4; Zhou, Ting-Lan 4; Qiu, Guofu 4; Huan, Xiajuan 3; Miao, Ze-Hong 3; Yang, Sheng-Ping 4; Cao, Shugeng 2; Fan, Fengkai 1; Cai, You-Sheng 2,4
刊名	PLANTA MEDICA
	2018-10
卷号	84 期号:15 页码:1127-1133
关键词	Tabernaemontana bufalina Apocynaceae monoterpenoid indole alkaloids cytotoxicity
ISSN号	0032-0943
DOI	10.1055/a-0608-4988
文献子类	Article
英文摘要	Three new bisindole alkaloids, 3'-(2-oxopropyl)-19,20-dihydrotabernamine (1), 3'-(2-oxopropyl)-ervahanine B (2), 19,20-dihydrovobparicine (3), and 20 known compounds were isolated from the aerial parts of Tabernaemontana bufalina. The structures of these alkaloids were elucidated using spectroscopic methods. The absolute configurations of 1-3 were determined by the circular dichroic exciton chirality method. Compounds 1-23 were screened for their cytotoxicity against two human cancer cell lines, A-549 and MCF-7. Ten compounds (1-3, 10, 14, 16, 17, 19, 22, and 23) exhibited inhibitory effects against the two human cancer cells with IC50 values of 1.19 similar to 6.13 mu M.
资助项目	National Natural Science Foundation of China[21402146] ; National Natural Science Foundation of China[31400732] ; Natural Science Foundation of Hubei Province[2014CFB567] ; Natural Science Foundation of Hubei Province[2015CFB421] ; open project of Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Ingredients[HLPAI2014001]
WOS关键词	DIMERIC INDOLE ALKALOIDS ; ERVATAMIA-HAINANENSIS ; APOCYNACEAE ; DIVARICATA ; APOPTOSIS ; ELEGANS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000446603200006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279559]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Cai, You-Sheng
作者单位	1.Hubei Univ Educ, Coll Chem & Life Sci, Hubei Key Lab Purificat & Applicat Plant Anticanc, Wuhan, Hubei, Peoples R China 2.Univ Hawaii, Daniel K Inouye Coll Pharm, Dept Pharmaceut Sci, Hilo, HI 96720 USA; 3.Chinese Acad Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 4.Wuhan Univ, Sch Pharmaceut Sci, Inst TCM & Nat Prod, Wuhan 430071, Hubei, Peoples R China;
推荐引用方式 GB/T 7714	Zhou, Si-Yuan,Zhou, Ting-Lan,Qiu, Guofu,et al. Three New Cytotoxic Monoterpenoid Bisindole Alkaloids from Tabernaemontana bufalina[J]. PLANTA MEDICA,2018,84(15):1127-1133.
APA	Zhou, Si-Yuan.,Zhou, Ting-Lan.,Qiu, Guofu.,Huan, Xiajuan.,Miao, Ze-Hong.,...&Cai, You-Sheng.(2018).Three New Cytotoxic Monoterpenoid Bisindole Alkaloids from Tabernaemontana bufalina.PLANTA MEDICA,84(15),1127-1133.
MLA	Zhou, Si-Yuan,et al."Three New Cytotoxic Monoterpenoid Bisindole Alkaloids from Tabernaemontana bufalina".PLANTA MEDICA 84.15(2018):1127-1133.