Alkaloids from the Leaves of Daphniphyllum subverticillatum

doi:10.1021/np9003799

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Alkaloids from the Leaves of Daphniphyllum subverticillatum
	Zhang, Chuan-Rui; Liu, Hong-Bing; Feng, Teng; Zhu, Jian-Yong; Geng, Mei-Yu; Yue, Jian-Min
刊名	JOURNAL OF NATURAL PRODUCTS
	2009-09
卷号	72 期号:9 页码:1669-1672
ISSN号	0163-3864
DOI	10.1021/np9003799
文献子类	Article
英文摘要	Four new alkaloids, 17-hydroxydaphnigraciline (1), subdaphnidine A (2), daphnezomine L methyl ester (3), and 11-hydroxycodaphniphylline (4), along with 24 known analogues, were isolated from the leaves of Daphniphyllum subverticillatum. The structures of 1-4 were elucidated on the basis of spectroscopic methods and from chemical evidence. Daphnilongeridine (5) showed cytotoxicity against several tumor cell lines at IC50 values in the range 2.4-9.7 mu M and against the HMEC human microvascular endothelial cell line with an IC50 of 2.7 mu M.
资助项目	National Natural Science Foundation[30630072] ; National Natural Science Foundation[30721005]
WOS关键词	GRACILE GAUGE ; LONGERACEMOSUM ; HUMILE ; CODAPHNIPHYLLINE ; DAPHNEZOMINES ; CALYCINUM ; PAXIANUM ; SKELETON ; ASSAY
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000270855600021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279150]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yue, Jian-Min
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Chuan-Rui,Liu, Hong-Bing,Feng, Teng,et al. Alkaloids from the Leaves of Daphniphyllum subverticillatum[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(9):1669-1672.
APA	Zhang, Chuan-Rui,Liu, Hong-Bing,Feng, Teng,Zhu, Jian-Yong,Geng, Mei-Yu,&Yue, Jian-Min.(2009).Alkaloids from the Leaves of Daphniphyllum subverticillatum.JOURNAL OF NATURAL PRODUCTS,72(9),1669-1672.
MLA	Zhang, Chuan-Rui,et al."Alkaloids from the Leaves of Daphniphyllum subverticillatum".JOURNAL OF NATURAL PRODUCTS 72.9(2009):1669-1672.