Stereoselective Synthesis of Methyl Spongoate, a New Steroid with Potent Antitumor Activities

doi:10.1055/s-0029-1218567

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	Stereoselective Synthesis of Methyl Spongoate, a New Steroid with Potent Antitumor Activities
	Gong, Jing-Xu 2; Miao, Ze-Hong 2; Yao, Li-Gong 2; Ding, Jian2 ; Kurtan, Tibor 1; Guo, Yue-Wei2
刊名	SYNLETT
	2010-02
期号	3 页码:480-482
关键词	steroids methyl spongoate stereoselective synthesis diastereoselective alkylation cytotoxicity
ISSN号	0936-5214
DOI	10.1055/s-0029-1218567
文献子类	Article
英文摘要	The stereoselective synthesis of methyl spongoate, a naturally occurring new steroid derivative with an unusual C-20 methoxycarbonyl group and potent antitumor activities, was achieved starting from the commercially available pregnenolone acetate in 11% overall yield.
资助项目	National Marine '863' Project[2006AA09Z447] ; National Marine '863' Project[2006AA09Z412] ; CAS Key Project[SIMM0907KF-09] ; Hungarian-Chinese Intergovermental S&T Cooperation Programme[00000000]
WOS关键词	LISSOCLINOTOXIN-A ; DERIVATIVES ; VARACIN
WOS研究方向	Chemistry
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000274233900029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278988]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Guo, Yue-Wei
作者单位	1.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Gong, Jing-Xu,Miao, Ze-Hong,Yao, Li-Gong,et al. Stereoselective Synthesis of Methyl Spongoate, a New Steroid with Potent Antitumor Activities[J]. SYNLETT,2010(3):480-482.
APA	Gong, Jing-Xu,Miao, Ze-Hong,Yao, Li-Gong,Ding, Jian,Kurtan, Tibor,&Guo, Yue-Wei.(2010).Stereoselective Synthesis of Methyl Spongoate, a New Steroid with Potent Antitumor Activities.SYNLETT(3),480-482.
MLA	Gong, Jing-Xu,et al."Stereoselective Synthesis of Methyl Spongoate, a New Steroid with Potent Antitumor Activities".SYNLETT .3(2010):480-482.