Effects of the Aqueous Extract of Salvia Miltiorrhiza (Danshen) and its Magnesium Tanshinoate B-enriched Form on Blood Pressure

doi:10.1002/ptr.3047

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	Effects of the Aqueous Extract of Salvia Miltiorrhiza (Danshen) and its Magnesium Tanshinoate B-enriched Form on Blood Pressure
	Leung, S. W. S.1; Zhu, D-Y.2; Man, R. Y. K.1
刊名	PHYTOTHERAPY RESEARCH
	2010-05
卷号	24 期号:5 页码:769-774
关键词	danshen extract magnesium tanshinoate B blood pressure hypertension Chinese medicine
ISSN号	0951-418X
DOI	10.1002/ptr.3047
文献子类	Article
英文摘要	Danshen is the dried root and rhizome of the Chinese medicinal plant Salvia miltiorrhiza Bunge (Labiatae), which has been used to treat hypertension and myocardial infarction. One of its water-soluble active components is magnesium tanshinoate B (MTB). The present study examined and compared the cardiovascular effects of the water-soluble extract of danshen (SME) and its MTB-enriched form (containing 70% of MTB (MTB70)). Anaesthetized rats were infused intravenously with saline or phenylephrine to achieve a normal or elevated blood pressure, respectively. Different doses of SME, MTB70 or vehicle were then injected intravenously and their effect on blood pressure was monitored. The results indicate that SME and MTB70 reduce blood pressure dose-dependently. Independently of the initial blood pressure, SME caused a smaller reduction in blood pressure than MTB70. In rats infused with phenylephrine, MTB70 caused greater decreases in blood pressure than in rats infused with saline, while the responses to SME did not differ between the two groups. From these findings, it appears that MTB is one of the major components responsible for the cardiovascular effects of danshen, and that the beneficial cardiovascular effect of the extract is more prominent under conditions of elevated blood pressure. Copyright (C) 2009 John Wiley & Sons, Ltd.
资助项目	Committee on Research and Conference Grant, University of Hong Kong[00000000]
WOS关键词	RAT CORONARY-ARTERY ; LITHOSPERMIC ACID-B ; MASS-SPECTROMETRY ; NITRIC-OXIDE ; LIQUID-CHROMATOGRAPHY ; ENDOTHELIAL-CELLS ; CALCIUM-CHANNELS ; ACTIVE COMPONENT ; INHIBITION ; CRYPTOTANSHINONE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000277961600023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278913]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Leung, S. W. S.
作者单位	1.Univ Hong Kong, Dept Pharmacol & Pharm, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Leung, S. W. S.,Zhu, D-Y.,Man, R. Y. K.. Effects of the Aqueous Extract of Salvia Miltiorrhiza (Danshen) and its Magnesium Tanshinoate B-enriched Form on Blood Pressure[J]. PHYTOTHERAPY RESEARCH,2010,24(5):769-774.
APA	Leung, S. W. S.,Zhu, D-Y.,&Man, R. Y. K..(2010).Effects of the Aqueous Extract of Salvia Miltiorrhiza (Danshen) and its Magnesium Tanshinoate B-enriched Form on Blood Pressure.PHYTOTHERAPY RESEARCH,24(5),769-774.
MLA	Leung, S. W. S.,et al."Effects of the Aqueous Extract of Salvia Miltiorrhiza (Danshen) and its Magnesium Tanshinoate B-enriched Form on Blood Pressure".PHYTOTHERAPY RESEARCH 24.5(2010):769-774.