New and Practical Synthesis of N-(3-Cyano-7-ethoxy-4-oxo-1, 4-dihydroquinolin-6-yl)acetamide

doi:10.1002/jhet.1901

	New and Practical Synthesis of N-(3-Cyano-7-ethoxy-4-oxo-1, 4-dihydroquinolin-6-yl)acetamide
	Ma, Wenpeng 3; Mao, Yongjun 2; Xie, Kai 1; Zhu, Qifeng 1; Zhang, Rongxia2 ; Shen, Jingshan2 ; Sun, Hongbin 3
刊名	JOURNAL OF HETEROCYCLIC CHEMISTRY
	2014-05
卷号	51 期号:3 页码:866-868
ISSN号	0022-152X
DOI	10.1002/jhet.1901
文献子类	Article
英文摘要	New and practical synthetic route of N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide (1) is described, through the cyclization of 2-aminophenyl-ethanone (12) with N,N-dimethylformamide dimethylacetal. The overall yield of 1 obtained from this process is 46% (five steps) with a purity of >99% (HPLC).
资助项目	National Science and Technology Major Project[2012ZX09301001-001] ; Key Project of Science and Technology of Shanghai[10431902800]
WOS关键词	ADDITION-ELIMINATION REACTION ; KINASE-ACTIVITY ; INHIBITORS ; OPTIMIZATION ; DERIVATIVES ; DISCOVERY ; SUBSTRATE ; AGENTS ; HER-2 ; EGFR
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000337560000050
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277086]
专题	成果转移转化处药物化学研究室
通讯作者	Sun, Hongbin
作者单位	1.Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.China Pharmaceut Univ, Nanjing 210009, Jiangsu, Peoples R China;
推荐引用方式 GB/T 7714	Ma, Wenpeng,Mao, Yongjun,Xie, Kai,et al. New and Practical Synthesis of N-(3-Cyano-7-ethoxy-4-oxo-1, 4-dihydroquinolin-6-yl)acetamide[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2014,51(3):866-868.
APA	Ma, Wenpeng.,Mao, Yongjun.,Xie, Kai.,Zhu, Qifeng.,Zhang, Rongxia.,...&Sun, Hongbin.(2014).New and Practical Synthesis of N-(3-Cyano-7-ethoxy-4-oxo-1, 4-dihydroquinolin-6-yl)acetamide.JOURNAL OF HETEROCYCLIC CHEMISTRY,51(3),866-868.
MLA	Ma, Wenpeng,et al."New and Practical Synthesis of N-(3-Cyano-7-ethoxy-4-oxo-1, 4-dihydroquinolin-6-yl)acetamide".JOURNAL OF HETEROCYCLIC CHEMISTRY 51.3(2014):866-868.