Small molecules from natural sources, targeting signaling pathways in diabetes

doi:10.1016/j.bbagrm.2010.06.004

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	Small molecules from natural sources, targeting signaling pathways in diabetes
	Liu, Qiong; Chen, Lili; Hu, Lihong; Guo, Yuewei; Shen, Xu
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
	2010-10
卷号	1799 期号:10-12 页码:854-865
关键词	Natural product Diabetes Insulin AMP-activated protein kinase Endoplasmic reticulum stress
ISSN号	1874-9399
DOI	10.1016/j.bbagrm.2010.06.004
文献子类	Review
英文摘要	Diabetes mellitus (DM) is a metabolic disease caused by genetic or environmental factors. It has rendered a severe menace to the middle-aged and elderly, while there is still lack of efficient drugs against this disease. The pathogenic mechanism for DM is complex, and the complicated networks related to this disease involve distinct signaling pathways. Currently, discovery of potential modulators targeting these pathways has become a potent approach for anti-diabetic drug lead compound development. Compared with synthetic compounds, natural products provide inherent larger-scale structural diversity and have been the major resource of bioactive agents for new drug discovery. To date, more and more active components from plants or marine organisms have been reported to regulate diabetic pathophysiological signaling pathways and exhibit anti-diabetic activity. This review will summarize the regulation of natural small molecules on some key signaling pathways involved in DM. These pathways include insulin signaling pathway, carbohydrate metabolism pathway, the pathways involving insulin secretion and PPAR regulation, endoplasmic reticulum (ER) stress and inflammation related pathways and chromatin modification pathways. (C) 2010 Elsevier B.V. All rights reserved.
资助项目	State Key Program of Basic Research of China[2010CB912501] ; State Key Program of Basic Research of China[2007AA02Z147] ; National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[30801415] ; National Natural Science Foundation of China[30890044] ; National Natural Science Foundation of China[20721003] ; Key New Drug Creation and Manufacturing Program[2009ZX09301-001] ; Shanghai Rising-Star Program[09QA1406800]
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; ACTIVATED PROTEIN-KINASE ; OCCURRING PENTACYCLIC TRITERPENES ; TYROSINE-PHOSPHATASE 1B ; INDUCED XBP1 ACTIVATION ; NF-KAPPA-B ; ER STRESS ; GLYCOGEN-PHOSPHORYLASE ; INSULIN-RESISTANCE ; OLEANOLIC ACID
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000285816500018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278754]
专题	生物技术药物研发中心（筹）中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第三研究室
通讯作者	Chen, Lili
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qiong,Chen, Lili,Hu, Lihong,et al. Small molecules from natural sources, targeting signaling pathways in diabetes[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2010,1799(10-12):854-865.
APA	Liu, Qiong,Chen, Lili,Hu, Lihong,Guo, Yuewei,&Shen, Xu.(2010).Small molecules from natural sources, targeting signaling pathways in diabetes.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1799(10-12),854-865.
MLA	Liu, Qiong,et al."Small molecules from natural sources, targeting signaling pathways in diabetes".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1799.10-12(2010):854-865.