Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component

doi:10.1002/ejoc.201001118

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	Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component
	Wang, Jie 1; Zhou, Pengfei 1; Wang, Yang 1,2
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2011-01
期号	2 页码:264-270
关键词	C-H activation Friedel-Crafts reaction Lewis acids Carbocations Alkanes Alkylation
ISSN号	1434-193X
DOI	10.1002/ejoc.201001118
文献子类	Article
英文摘要	A highly efficient and selective intramolecular Friedel-Crafts reaction of 3-methylbutyl or 4-methylpentyl-substituted aromatics has been developed using a carbocation relay strategy through selective sp(3) C-H bond activation, providing a facile and cost-effective approach for the construction of benzocyclic compounds. A variety of 1,1-dimethylindane and naphthalene derivatives have been prepared from very simple starting materials in good yields with high selectivity. The present strategy has provided a new example of a Friedel-Crafts reaction with alkanes as the alkylating component and constitutes a convenient approach to selective C-H bond activation and functionalization of alkane derivatives.
资助项目	National Natural Science Foundation of China[20972033] ; National Drug Innovative Program[2009ZX09301-011] ; State Key Laboratory of Drug research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[00000000]
WOS关键词	REGIOSPECIFIC FUNCTIONALIZATION ; ARYLATION ; COMPLEXES ; PHENOLS ; METHYL
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000286964500008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278646]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Wang, Yang
作者单位	1.Fudan Univ, Dept Med Chem, Sch Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jie,Zhou, Pengfei,Wang, Yang. Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2011(2):264-270.
APA	Wang, Jie,Zhou, Pengfei,&Wang, Yang.(2011).Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2),264-270.
MLA	Wang, Jie,et al."Selective sp(3) C-H Bond Activation Based on a Carbocation Relay: Friedel-Crafts Reaction with Alkanes as the Alkylating Component".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .2(2011):264-270.