Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2 ',1 ':2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents

doi:10.1002/ejoc.201200542

	Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2 ',1 ':2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents
	Zhou, Huayong 1; Wang, Wei 1; Khorev, Oleg 2; Zhang, Yongliang 1; Miao, Zehong 1; Meng, Tao1 ; Shen, Jingkang 1
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2012-10
期号	28 页码:5585-5594
关键词	Heterocycles Alkynes Silver Multicomponent reactions Antiproliferation
ISSN号	1434-193X
DOI	10.1002/ejoc.201200542
文献子类	Article
英文摘要	A new practical method for the synthesis of tetracyclic pyrido[2',1':2,3]imidazo[5,1-a]isoquinolinium compounds by a Yb(OTf)3/AgOTf-catalyzed (Tf = triflate) three-component domino reaction was developed. Significantly, the strategy presents a straightforward and efficient approach to constructing a series of compounds with potent cytotoxic activities.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09103-101-026] ; National Natural Science Foundation of China[81001355]
WOS关键词	TRIFLATE-CATALYZED REACTION ; ASYMMETRIC MULTICOMPONENT REACTIONS ; HISTONE DEACETYLASE INHIBITOR ; QUADRUPLEX DNA-BINDING ; SILVER TRIFLATE ; ISOQUINOLINE ALKALOIDS ; INTRAMOLECULAR CYCLIZATION ; COMBINATORIAL SYNTHESIS ; MOLECULAR COMPLEXITY ; EFFICIENT APPROACH
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000308939800018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277928]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Meng, Tao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
推荐引用方式 GB/T 7714	Zhou, Huayong,Wang, Wei,Khorev, Oleg,et al. Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2 ',1 ':2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(28):5585-5594.
APA	Zhou, Huayong.,Wang, Wei.,Khorev, Oleg.,Zhang, Yongliang.,Miao, Zehong.,...&Shen, Jingkang.(2012).Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2 ',1 ':2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(28),5585-5594.
MLA	Zhou, Huayong,et al."Three-Component, One-Pot Sequential Synthesis of Tetracyclic Pyrido[2 ',1 ':2,3]imidazo[5,1-a]isoquinolinium Compounds as Potent Anticancer Agents".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .28(2012):5585-5594.