Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives

doi:10.1021/ol4004542

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	Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives
	Chen, Xianjie 1,2; Chen, Hui 1; Ji, Xun 1; Jiang, Hualiang1,2 ; Yao, Zhu-Jun 2; Liu, Hong1
刊名	ORGANIC LETTERS
	2013-04-19
卷号	15 期号:8 页码:1846-1849
ISSN号	1523-7060
DOI	10.1021/ol4004542
文献子类	Article
英文摘要	An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).
资助项目	National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2009CB918502] ; National Basic Research Program of China[2012CB518005] ; NSFC[21021063] ; NSFC[91229204] ; NSFC[81025017] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] ; Silver Project[260644]
WOS关键词	MANNICH-TYPE REACTION ; ENANTIOSELECTIVE SYNTHESIS ; ALPHA,BETA-DIAMINO ACIDS ; AMINO-ACIDS ; THIOUREA ; HYDROAMINATION ; ALDIMINES ; CASCADE ; ALKYNES ; IMINES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000318001400015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277650]
专题	药物发现与设计中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室
通讯作者	Jiang, Hualiang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Nanjing Univ, Sch Chem & Chem Engn, Nanjing Natl Lab Microstruct, Nanjing 210093, Jiangsu, Peoples R China;
推荐引用方式 GB/T 7714	Chen, Xianjie,Chen, Hui,Ji, Xun,et al. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives[J]. ORGANIC LETTERS,2013,15(8):1846-1849.
APA	Chen, Xianjie,Chen, Hui,Ji, Xun,Jiang, Hualiang,Yao, Zhu-Jun,&Liu, Hong.(2013).Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives.ORGANIC LETTERS,15(8),1846-1849.
MLA	Chen, Xianjie,et al."Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2 '-oxindole] Derivatives".ORGANIC LETTERS 15.8(2013):1846-1849.