Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.

doi:10.1016/j.bmc.2014.05.042

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	Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.
	Liu, Li-Ping 1; Han, Kun 2; Chen, Wei 1; Zhang, Ying-Ying 1; Tong, Lin-Jiang 2; Peng, Ting 2; Xie, Hua2 ; Ding, Jian2 ; Wang, Hong-Bing 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2014-08-01
卷号	22 期号:15 页码:4198-4203
关键词	Stellera chamaejasme L. Cytotoxic activity Topoisomerase II Apoptosis
ISSN号	0968-0896
DOI	10.1016/j.bmc.2014.05.042
文献子类	Article
英文摘要	Three new compounds, including one daphnane diterpene (1), one sesquiterpene (6), and one lignan (7) have been isolated from the Stellera chamaejasme L., together with five other known compounds, including four daphnane diterpenenoids (2-5) and one lignan (8). The structures of the new compounds were elucidated by spectroscopic analysis. The cytotoxicities of compounds 1-8 towards human lung adenocarcinoma cells (A549 cells) were evaluated using a sulforhodamine B assay. All of the compounds displayed significant cytotoxicity, with IC50 values in the ranging of 0.2 nM to 2.0 mu M. Mechanistic studies revealed that the antitumor activities of compounds 1-3 and 7 were derived from their inhibition of topoisomerase II (Topo II). Furthermore, as a Topo II inhibitor, compound 1 was found to effectively induced G2-M phase cell cycle arrest and apoptosis in cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation[81001369] ; National Natural Science Foundation[31170327] ; National Natural Science Foundation[81173080] ; National Natural Science Foundation[81321092] ; Fundamental Research Funds for the Central Universities of the People's Republic of China[00000000]
WOS关键词	POTENT ANTITUMOR ACTIVITIES ; PISCICIDAL CONSTITUENTS ; DAPHNANE DITERPENES ; APOPTOSIS ; DERIVATIVES ; COUMARINS ; AGENTS ; ARREST
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000339859700043
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276971]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xie, Hua
作者单位	1.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Liu, Li-Ping,Han, Kun,Chen, Wei,et al. Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(15):4198-4203.
APA	Liu, Li-Ping.,Han, Kun.,Chen, Wei.,Zhang, Ying-Ying.,Tong, Lin-Jiang.,...&Wang, Hong-Bing.(2014).Topoisomerase II inhibitors from the roots of Stellera chamaejasme L..BIOORGANIC & MEDICINAL CHEMISTRY,22(15),4198-4203.
MLA	Liu, Li-Ping,et al."Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.".BIOORGANIC & MEDICINAL CHEMISTRY 22.15(2014):4198-4203.