CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation

doi:10.1007/s12013-014-0011-8

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	CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation
	Wang, Lin 1,2; Huang, Juxiang 1; Jiang, Minghu 3; Chen, Qingchun 1; Jiang, Zhenfu 4; Feng, Haitao 5
刊名	CELL BIOCHEMISTRY AND BIOPHYSICS
	2014-11
卷号	70 期号:2 页码:1011-1016
关键词	CAMK1 Human hepatocellular carcinoma (HCC) Phosphoinositide signal-mediated protein sorting and transport network Biocomputation
ISSN号	1085-9195
DOI	10.1007/s12013-014-0011-8
文献子类	Article
英文摘要	We data-analyzed and constructed the high-expression CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) compared with low-expression (fold change >= 2) no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) in GEO data set, using integration of gene regulatory network inference method with gene ontology (GO). Our result showed that CAMK1 transport subnetwork upstream KCNQ3, LCN2, NKX2_ 5, NUP62, SORT1, STX1A activated CAMK1, and downstream CAMK1-activated AFP, ENAH, KPNA2, SLC4A3; CAMK1 signal subnetwork upstream BRCA1, DKK1, GPSM2, LEF1, NR5A1, NUP62, SORT1, SSTR5, TBL3 activated CAMK1, and downstream CAMK1-activated MAP2K6, SFRP4, SSTR5, TSHB, UBE2C in HCC. We proposed that CAMK1 activated network enhanced endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, Golgi to endosome transport, intracellular protein transmembrane transport, intracellular protein transport, ion transport, mRNA transport, plasma membrane to endosome transport, potassium ion transport, protein transport, vesicle-mediated transport, anion transport, intracellular transport, androgen receptor signaling pathway, cell surface receptor-linked signal transduction, hormone-mediated signaling, induction of apoptosis by extracellular signals, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, signal transduction resulting in induction of apoptosis, phosphoinositide-mediated signaling, Wnt receptor signaling pathway, as a result of inducing phosphoinositide signal-mediated protein sorting, and transport in HCC. Our hypothesis was verified by CAMK1 functional regulation subnetwork containing positive regulation of calcium ion transport via voltage gated calcium channel, cell proliferation, DNA repair, exocytosis, I-kappaB kinase/NF-kappaB cascade, immunoglobulin-mediated immune response, mast cell activation, natural killer cell-mediated cytotoxicity directed against tumor cell target, protein ubiquitination, sodium ion transport, survival gene product activity, T cell-mediated cytotoxicity, transcription, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, transcription via serum response element binding, exit from mitosis, ubiquitin ligase activity during mitotic cell cycle, regulation of angiogenesis, apoptosis, cell growth, cell proliferation, cyclin-dependent protein kinase activity, gene expression, insulin secretion, steroid biosynthesis, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter, cell cycle, cell migration, DNA recombination, and protein metabolism; also by CAMK1 negative functional regulation subnetwork including negative regulation of apoptosis, cell proliferation, centriole replication, fatty acid biosynthesis, lipoprotein lipase activity, MAPK activity, progression through cell cycle, transcription, transcription from RNA polymerase II promoter, cell growth, phosphorylation, and ubiquitin ligase activity during mitotic cell cycle in HCC.
资助项目	National Natural Science Foundation of China[61171114] ; State Key Laboratory of Drug Research[SIMM1302KF] ; Automatical Scientific Planning of Tsinghua University[20111081023] ; Automatical Scientific Planning of Tsinghua University[20111081010] ; Fundamental Research Funds for the Central Universities (BUPT)[2014RC0201]
WOS关键词	CYCLE COMPUTATIONAL NETWORK ; HEPATITIS/CIRRHOSIS ; TRANSFORMATION ; CONSTRUCTION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
语种	英语
出版者	HUMANA PRESS INC
WOS记录号	WOS:000343143500035
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276860]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Wang, Lin
作者单位	1.Beijing Univ Posts & Telecommun, Sch Elect Engn, Biomed Ctr, Beijing 100876, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Tsinghua Univ, Lab Computat Linguist, Sch Humanities & Social Sci, Beijing 100084, Peoples R China; 4.China Univ Min & Technol, Sch Mech Elect & Informat Engn, Beijing 100083, Peoples R China; 5.Heilongjiang Univ Chinese Med, Dean Dept, Harbin 150040, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lin,Huang, Juxiang,Jiang, Minghu,et al. CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,70(2):1011-1016.
APA	Wang, Lin,Huang, Juxiang,Jiang, Minghu,Chen, Qingchun,Jiang, Zhenfu,&Feng, Haitao.(2014).CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.CELL BIOCHEMISTRY AND BIOPHYSICS,70(2),1011-1016.
MLA	Wang, Lin,et al."CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation".CELL BIOCHEMISTRY AND BIOPHYSICS 70.2(2014):1011-1016.