9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis

doi:10.1016/j.steroids.2014.08.027

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	9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis
	Chen, Wen-Ting; Liu, Hai-Li; Yao, Li-Gong; Guo, Yue-Wei
刊名	STEROIDS
	2014-12-15
卷号	92 页码:56-61
关键词	Soft coral Sarcophyton trocheliophorum Sinularia flexibilis 9,11-Secosteroid Polyhydroxylated steroid
ISSN号	0039-128X
DOI	10.1016/j.steroids.2014.08.027
文献子类	Article
英文摘要	A new 9,11-secosteroid, 25(26)-dehydrosarcomilasterol (1), two new polyhydroxylated steroids, 7 alpha-hydroxy-crassarosterol A (2) and 11-acetoxy-7 alpha-hydroxy-crassarosterol A (3), together with three known related ones (4-6), were isolated from the South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis, respectively. The structures of the new steroids were elucidated on the basis of extensive spectroscopic analyses, comparison with the literature data and chemical correlation. Compound 2 exhibited a moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 33.05 mu M. Compounds 1-3 showed weak in vitro cytotoxicities against the tumor cell lines 1(562 and HL-60. (C) 2014 Elsevier Inc. All rights reserved.
资助项目	National Marine '863' Projects[2011AA09070102] ; National Marine '863' Projects[2013AA092902] ; Natural Science Foundation of China[81273430] ; SKLDR/SIMM Project[SIMM1203ZZ-03] ; SKLNM/CPU Project[SKLNMKF201412] ; EU[246987]
WOS关键词	POLYOXYGENATED STEROIDS ; SUBERGORGIA-SUBEROSA ; MUSA-SAPIENTUM ; INDIAN-OCEAN ; DITERPENOIDS ; LEPTOCLADOS ; METABOLITES ; INHIBITOR ; CHEMISTRY
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000347134300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276800]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Guo, Yue-Wei
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wen-Ting,Liu, Hai-Li,Yao, Li-Gong,et al. 9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis[J]. STEROIDS,2014,92:56-61.
APA	Chen, Wen-Ting,Liu, Hai-Li,Yao, Li-Gong,&Guo, Yue-Wei.(2014).9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis.STEROIDS,92,56-61.
MLA	Chen, Wen-Ting,et al."9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis".STEROIDS 92(2014):56-61.