Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel

doi:10.1016/j.biomaterials.2015.01.049

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	Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel
	Tang, Shan 1,2; Yin, Qi1,2 ; Su, Jinghan 1,2; Sun, Huiping 1,2; Meng, Qingshuo 1,2; Chen, Yi1,2 ; Chen, Lingli1,2 ; Huang, Yongzhuo1,2 ; Gu, Wangwen1,2 ; Xu, Minghua1,2
刊名	BIOMATERIALS
	2015-04
卷号	48 页码:1-15
关键词	Metastasis Co-delivery pH-sensitive Poly (beta-amino ester) Paclitaxel RNA interference
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2015.01.049
文献子类	Article
英文摘要	Breast cancer is the most vicious killer for women's health, while metastasis is the main culprit, which leads to failure of treatment by increasing relapse rate. In this work, a new complexes nanoparticles loading two siRNA (Snail siRNA (siSna) and Twist siRNA (siTwi)) and paclitaxel (PTX) were designed and constructed using two new amphiphilic polymer, polyethyleneimine-block-poly[(1,4-butanediol)-diacrylate-P-5-hydroxyamylamine] (PEI-PDHA) and polyethylene glycol-block-poly1(1,4-butanediol)-diacrylate-0-5-hydroxyamylamine] (PEG-PDHA) by self-assembly. The experimental results showed that in the 4T1 tumor-bearing mice models, PEI-PDHA/PEG-PDHAIPTX/siSna/siTwi) complex nanoparticles (PPSTs) raised the accumulation and retention of both PTX and siRNA in tumor after administrated intravenously, resulted in the strong inhibition of the tumor growth and metastasis simultaneously. It was found that co-delivery of siSna and siTwi had more significant anti-metastasis effect than delivering a single siRNA, as a result of simultaneously inhibiting the motility of cancer cells and degradation of ECM. Therefore, PPSTs could be a promising co-delivery vector for effective therapy of metastatic breast cancer. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81230029] ; National Basic Research Program of China[2014CB931902] ; National Basic Research Program of China[2013CB932704]
WOS关键词	EPITHELIAL-MESENCHYMAL TRANSITIONS ; E-CADHERIN ; TRANSCRIPTION FACTORS ; HEPATOCELLULAR-CARCINOMA ; TUMOR PROGRESSION ; EXPRESSION ; TWIST ; CELLS ; SNAIL ; INVASION
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000350928600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276593]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yin, Qi
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Tang, Shan,Yin, Qi,Su, Jinghan,et al. Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel[J]. BIOMATERIALS,2015,48:1-15.
APA	Tang, Shan.,Yin, Qi.,Su, Jinghan.,Sun, Huiping.,Meng, Qingshuo.,...&Li, Yaping.(2015).Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel.BIOMATERIALS,48,1-15.
MLA	Tang, Shan,et al."Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel".BIOMATERIALS 48(2015):1-15.