Lysophospholipids from the Guangxi Sponge Spirastrella purpurea

doi:10.1007/s11745-015-4028-6

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Lysophospholipids from the Guangxi Sponge Spirastrella purpurea
	Lin, Kun 1; Yang, Peng 1; Yang, Hui 1; Liu, Ai-Hong 2; Yao, Li-Gong 3; Guo, Yue-Wei3 ; Mao, Shui-Chun 1
刊名	LIPIDS
	2015-07
卷号	50 期号:7 页码:697-703
关键词	Sponge Spirastrella purpurea Marine natural products Lysophospholipids Guangxi Antifungal activity Neuroprotective activity HPLC NMR
ISSN号	0024-4201
DOI	10.1007/s11745-015-4028-6
文献子类	Article
英文摘要	Four known (1-4) and two new (5 and 6) lysophospholipids were isolated from the sponge Spirastrella purpurea from Weizhou Island, Guangxi Autonomous Region, China. The structures of the new compounds (5 and 6) were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments. The known compounds (1-4) were identified by comparison of their spectroscopic data and specific optical rotation with those reported in the literature. The isolated compounds displayed various moderate in vitro antifungal activities against four fungi (Cryptococcus neoformans, Candida glabrata, Trichophyton rubrum, and Aspergillus fumigatus), whereas they displayed no neuroprotective activity against A beta(25-35)-induced SH-SY5Y cell damage.
资助项目	National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; National Natural Science Foundation of China[21362024] ; Young Scientists Training Program of Jiangxi Province[20133BCB23004] ; Natural Science Foundation of Jiangxi Province[20114BAB205034] ; Foundation of Education Department of Jiangxi Province[GJJ12028]
WOS关键词	PLATELET-ACTIVATING-FACTOR ; ALGA CAULERPA-RACEMOSA ; ETHER PHOSPHOLIPIDS ; GUINEA-PIG ; LYSOPHOSPHATIDYLCHOLINES ; DERIVATIVES ; ARTHROPODS ; INHIBITORS ; INCONSTANS ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Nutrition & Dietetics
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000357280200009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276483]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Mao, Shui-Chun
作者单位	1.Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China; 2.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Lin, Kun,Yang, Peng,Yang, Hui,et al. Lysophospholipids from the Guangxi Sponge Spirastrella purpurea[J]. LIPIDS,2015,50(7):697-703.
APA	Lin, Kun.,Yang, Peng.,Yang, Hui.,Liu, Ai-Hong.,Yao, Li-Gong.,...&Mao, Shui-Chun.(2015).Lysophospholipids from the Guangxi Sponge Spirastrella purpurea.LIPIDS,50(7),697-703.
MLA	Lin, Kun,et al."Lysophospholipids from the Guangxi Sponge Spirastrella purpurea".LIPIDS 50.7(2015):697-703.