Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa

doi:10.1021/acs.jnatprod.5b00368

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物发现与设计中心

	Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa
	Zheng, Xiu-Mian 2,3,4; Meng, Fan-Wang 1,5; Geng, Fang 2,3; Qi, Meng 2,3; Luo, Cheng1 ; Yang, Li 2,3; Wang, Zheng-Tao 2,3
刊名	JOURNAL OF NATURAL PRODUCTS
	2015-11
卷号	78 期号:11 页码:2822-2826
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.5b00368
文献子类	Article
英文摘要	Two new alkaloids, plantadeprate A (1) and 1'-(4"-hydroxybutyl)-plantagoguanidinic acid (2), along with three known compounds, were isolated from the seeds of Plantago depressa. Their structures were elucidated by physical data analyses including NMR, MS, and electronic circular dichroism (ECD) methods. Plantadeprate A (1), a monoterpene zwitterionic guanidium, possesses a unique 5/5/6-tricyclic ring system. Its absolute configuration was determined by X-ray crystallography and computational methods. Compound 1, plumbagine D (3), and plantagoguanidinic acid (4) exhibited potential antihyperglycemic properties attributed to suppression of hepatic gluconeogenesis with inhibitory rates of 8.2%, 18.5%, and 12.5% at 40 mu M, respectively.
资助项目	National S&T Major Special Projects of China[2012ZX09103201-045] ; "Shu-Guang Scholar" Project of Shanghai Municipal Education Commission[11SG41]
WOS关键词	ANGIOTENSIN-CONVERTING ENZYME ; PHENYLETHANOID GLYCOSIDES ; BIOLOGICAL-ACTIVITIES ; INHIBITORY-ACTIVITY ; ALKALOIDS ; ENERGIES ; GLUCOSE ; MODEL ; L.
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000366005800041
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276338]
专题	药物发现与设计中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yang, Li
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Key Lab Standardizat Chinese Med, Minist Educ, Shanghai 201203, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; 5.Shanghai Univ, Coll Sci, Dept Chem, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Xiu-Mian,Meng, Fan-Wang,Geng, Fang,et al. Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(11):2822-2826.
APA	Zheng, Xiu-Mian.,Meng, Fan-Wang.,Geng, Fang.,Qi, Meng.,Luo, Cheng.,...&Wang, Zheng-Tao.(2015).Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa.JOURNAL OF NATURAL PRODUCTS,78(11),2822-2826.
MLA	Zheng, Xiu-Mian,et al."Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa".JOURNAL OF NATURAL PRODUCTS 78.11(2015):2822-2826.