Cytotoxic tigliane-type diterpenoids from Croton tiglium | |
Zhang, Dong-Dong; Zhou, Bin; Yu, Jin-Hai; Xu, Cheng-Hui; Ding, Jian; Zhang, Hua; Yue, Jian-Min | |
刊名 | TETRAHEDRON |
2015-12-30 | |
卷号 | 71期号:52页码:9638-9644 |
关键词 | Croton tiglium Diterpenoid Tigliane Cytotoxicity |
ISSN号 | 0040-4020 |
DOI | 10.1016/j.tet.2015.10.070 |
文献子类 | Article |
英文摘要 | Chemical study on the twigs and leaves of Croton tiglium has led to the isolation of 11 new tigliane-type diterpenoids, crotignoids A-K(1-11), along with eight known analogues (12-19). The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. In vitro cytotoxic assays revealed moderate inhibition of compounds 1-10 toward human HL-60 and A549 tumor cells, with 1 exhibiting the strongest activity against HL-60 cell line with an IC50 value of 1.61 mu M. (C) 2015 Elsevier Ltd. All rights reserved. |
资助项目 | National Natural Science Foundation[81322045] |
WOS关键词 | PHORBOL ESTERS ; CLERODANE DITERPENOIDS ; PROTEIN-KINASE ; TONKINENSIS ; AGENTS ; EUPHORBIACEAE ; CONSTITUENTS ; INHIBITORS ; LEAVES ; ASSAY |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000366535800008 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/276280] |
专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 期刊编辑部 新药研究国家重点实验室 分析化学研究室 |
通讯作者 | Zhang, Hua |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Dong-Dong,Zhou, Bin,Yu, Jin-Hai,et al. Cytotoxic tigliane-type diterpenoids from Croton tiglium[J]. TETRAHEDRON,2015,71(52):9638-9644. |
APA | Zhang, Dong-Dong.,Zhou, Bin.,Yu, Jin-Hai.,Xu, Cheng-Hui.,Ding, Jian.,...&Yue, Jian-Min.(2015).Cytotoxic tigliane-type diterpenoids from Croton tiglium.TETRAHEDRON,71(52),9638-9644. |
MLA | Zhang, Dong-Dong,et al."Cytotoxic tigliane-type diterpenoids from Croton tiglium".TETRAHEDRON 71.52(2015):9638-9644. |
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