Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia

doi:10.1039/c5ob02296g

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia
	Zhang, Hua 1; Liu, Jia1 ; Gan, Li-She 2; Dalal, Seema 3,4; Cassera, Maria B.3,4; Yue, Jian-Min1
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2016
卷号	14 期号:3 页码:957-962
ISSN号	1477-0520
DOI	10.1039/c5ob02296g
文献子类	Article
英文摘要	Chemical investigation into the minor constituents of Aphanamixis grandifolia yielded three new diterpenoid dimers, aphadilactones E-G (1-3) featuring a new carbon skeleton. Their structures and absolute configurations were fully established by comprehensive spectroscopic data analysis and ECD calculation. Discovery of another two new dimers (4 and 5) suggested the structure of recently reported aphanamene A to be re-investigated. Compounds 1-5 showed moderate antimalarial activities with low micromolar IC50 values.
资助项目	National Natural Science Foundation of P. R. China[81322045] ; National Natural Science Foundation of P. R. China[81321092]
WOS关键词	APHADILACTONES A-D ; STEM BARKS ; CHEMICAL-CONSTITUENTS ; FRUITS ; TRITERPENOIDS ; DERIVATIVES ; LIMONOIDS ; RING
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000368687600020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276260]
专题	天然药物化学研究室中科院受体结构与功能重点实验室期刊编辑部新药研究国家重点实验室分析化学研究室
通讯作者	Yue, Jian-Min
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Zhejiang Univ, Inst Modern Chinese Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 3.Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA; 4.Virginia Polytech Inst & State Univ, Virginia Tech, Ctr Drug Discovery, MC 0308, Blacksburg, VA 24061 USA
推荐引用方式 GB/T 7714	Zhang, Hua,Liu, Jia,Gan, Li-She,et al. Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(3):957-962.
APA	Zhang, Hua,Liu, Jia,Gan, Li-She,Dalal, Seema,Cassera, Maria B.,&Yue, Jian-Min.(2016).Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia.ORGANIC & BIOMOLECULAR CHEMISTRY,14(3),957-962.
MLA	Zhang, Hua,et al."Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia".ORGANIC & BIOMOLECULAR CHEMISTRY 14.3(2016):957-962.