A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source

doi:10.1039/c6ra02424f

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source
	Sun, Guanglong; Lei, Min; Hu, Lihong
刊名	RSC ADVANCES
	2016
卷号	6 期号:34 页码:28442-28446
ISSN号	2046-2069
DOI	10.1039/c6ra02424f
文献子类	Article
英文摘要	A facile and efficient method for the synthesis of alkynones by a Pd-catalyzed carbonylative Sonogashira coupling reaction starting from aryl iodide, terminal alkyne and chloroform (CHCl3) as the CO source is described. This procedure proves that CHCl3 is a cheap and efficient CO source in the presence of CsOH center dot H2O as the base. Furthermore, it is applied successfully for themodification of natural products, such as vindoline and tabersonin, to obtain the corresponding products in good yields.
资助项目	National Natural Science Foundation of China[81273397] ; National Natural Science Foundation of China[81561148011] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104]
WOS关键词	PALLADIUM-CATALYZED CARBONYLATION ; 3-COMPONENT PYRIMIDINE SYNTHESIS ; EX-SITU GENERATION ; ONE-POT SYNTHESIS ; 2,5-DISUBSTITUTED FURANS ; ROOM-TEMPERATURE ; TERMINAL ALKYNES ; ACID-CHLORIDES ; KETONES ; YNONES
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000372610200033
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276237]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Lei, Min; Hu, Lihong
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Sun, Guanglong,Lei, Min,Hu, Lihong. A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source[J]. RSC ADVANCES,2016,6(34):28442-28446.
APA	Sun, Guanglong,Lei, Min,&Hu, Lihong.(2016).A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source.RSC ADVANCES,6(34),28442-28446.
MLA	Sun, Guanglong,et al."A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source".RSC ADVANCES 6.34(2016):28442-28446.