Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects

doi:10.1039/c6ra08986k

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	Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects
	Hu, Chang-Ling 2; Xiong, Juan 2; Gao, Li-Xin 3; Li, Jia3 ; Zeng, Huaqiang 1; Zou, Yike 4; Hu, Jin-Feng 2
刊名	RSC ADVANCES
	2016
卷号	6 期号:65 页码:60467-60478
ISSN号	2046-2069
DOI	10.1039/c6ra08986k
文献子类	Article
英文摘要	Rare and endangered plants have proven to be better sources for drug discovery than other botanic sources. Pinus dabeshanensis is an endangered plant listed in the China Plant Red Data Book, and has never been phytochemically investigated. In the present study, 11 new (dabeshanensins A-K, 1-11, resp.) and 28 related known naturally occurring diterpenoids were isolated from the shed trunk bark of this plant. The new structures were established by extensive spectroscopic methods and molecular modeling. Among them, dabeshanensin C (3) has an unprecedented bicyclo[3.3.1] nonane ring system (rings B and C) by oxidative cleavage of the C-6/C-7 bond followed by the formation of a new C-C bond between C-6 and C-12. The plausible biosynthetic pathway to 3 is briefly discussed. Dabeshanensins A (1) and J (10), 12-hydroxydehydroabietic acid (33), abieta-8,11,13,15-tetraen-18-oic acid (35), and 15-hydroxy-7-oxo-8,11,13-abietatrien-18-oic acid (37) showed significant inhibitory effects against the human protein tyrosine phosphatase 1B (PTP1B) enzyme, a key target for the treatment of type-II diabetes and obesity, with IC50 values ranging from 5.4 to 50.9 mu M.
资助项目	NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; National Basic Research Program of China (973 Program)[2013CB530700]
WOS关键词	TYROSINE-PHOSPHATASE 1B ; ARALIA-CONTINENTALIS ROOTS ; LARIX KAEMPFERI ; ABIES-GEORGEI ; ABIETANE-TYPE ; CONSTITUENTS ; LEAVES ; BIODIVERSITY ; METABOLITES ; HEARTWOOD
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000379351600066
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276214]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	Hu, Jin-Feng
作者单位	1.Inst Bioengn & Nanotechnol, 31 Biopolis Way, The Nanos 138669, Singapore; 2.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 4.Univ Penn, Dept Chem, 231 South 34 St, Philadelphia, PA 19104 USA
推荐引用方式 GB/T 7714	Hu, Chang-Ling,Xiong, Juan,Gao, Li-Xin,et al. Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects[J]. RSC ADVANCES,2016,6(65):60467-60478.
APA	Hu, Chang-Ling.,Xiong, Juan.,Gao, Li-Xin.,Li, Jia.,Zeng, Huaqiang.,...&Hu, Jin-Feng.(2016).Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects.RSC ADVANCES,6(65),60467-60478.
MLA	Hu, Chang-Ling,et al."Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects".RSC ADVANCES 6.65(2016):60467-60478.