One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones

doi:10.1039/c6ra21776a

	One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones
	Yang, Yuhong 1,2; Qi, Xueyu 1,2; Liu, Ruiling 1,2; He, Qian1,2 ; Yang, Chunhao1,2
刊名	RSC ADVANCES
	2016
卷号	6 期号:106 页码:103895-103898
ISSN号	2046-2069
DOI	10.1039/c6ra21776a
文献子类	Article
英文摘要	A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2,3-c]coumarins via a cascade reaction from chromones has been developed. This cascade reaction involves a Michael addition-Knoevenagel condensation-intramolecular cyclization. This transformation proceeds under mild conditions and gives various thieno[ 2,3-c]coumarins in good-to-excellent yields. The methodology is tolerant of a wide range of functional groups and applicable to library synthesis.
资助项目	National Natural Science Foundation of China[81321092] ; SKLDR/SIMM[SIMM1601ZZ-03]
WOS关键词	ETHYL MERCAPTOACETATE ; COUMARIN DERIVATIVES ; EFFICIENT SYNTHESIS ; RECEPTOR ; AGENTS ; BENZOPYRANONES ; REARRANGEMENT ; INHIBITORS ; COUMESTROL ; CATALYSIS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000388111900004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276189]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yang, Chunhao
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Yuhong,Qi, Xueyu,Liu, Ruiling,et al. One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones[J]. RSC ADVANCES,2016,6(106):103895-103898.
APA	Yang, Yuhong,Qi, Xueyu,Liu, Ruiling,He, Qian,&Yang, Chunhao.(2016).One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones.RSC ADVANCES,6(106),103895-103898.
MLA	Yang, Yuhong,et al."One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones".RSC ADVANCES 6.106(2016):103895-103898.