Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

doi:10.1016/j.phytochem.2016.03.006

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity
	Yao, Sheng2,3,4 ; To, Kenneth Kin-Wah 3,4,5; Ma, Liang 2,3,4; Yin, Chun 1,3,4; Tang, Chunping2,3,4 ; Chai, Stella 1,3,4; Ke, Chang-Qiang2,3,4 ; Lin, Ge 1,3,4; Ye, Yang2,3,4,6
刊名	PHYTOCHEMISTRY
	2016-06
卷号	126 页码:47-58
关键词	Marsdenia tenacissima Asclepiadaceae C-21 steroids Open-chain sugars Absolute configuration X-ray crystallography diffraction Chemoresistance reversal activity Structure elucidation
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2016.03.006
文献子类	Article
英文摘要	A polyoxypregnane aglycone,12 beta-O-acetyl-11 alpha-O-isobutyryltenacigenin B, and four polyoxypregnane glycosides with a pachybionic acid ester moiety, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandronyl)-11 alpha-O-isobutylyltenacigenin B, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandrony1)-11 alpha-O-tigloyltenacigenin B, 12 beta-O-acetyl-3-O-(6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-beta-D-oleandronyl)-11 alpha-O-2-methylbutylyltenacigenin B, and 12 beta-O-acetyl-3-O-glucopyranosyl-(1 -> 4)-6-deoxy-3-O-methyl-beta-D-allopyranosyl-(1 -> 4)-D-oleandronyl)-11 alpha-O-tigloyltenacigenin B, were isolated from the canes of Marsdenia tenacissima, together with a disaccharide derivative. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations were further determined by X-ray crystallographic analysis. With the exception of the disaccharide derivative, all five compounds are unusual naturally occurring polyoxypregnane glycosides bearing an open-chain sugar moiety. Two of these exhibit a wide spectrum of chemoresistance reversal activity, and potential mechanisms were studied accordingly. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Natural Science Funds of China[81302657] ; Ministry of Science and Technology[2010DFA30980] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; Youth Innovation Promotion Association CAS[00000000] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] ; Health and Medical Research Fund (HHSRF Project) from the Food and Health Bureau, HKSAR[08090481] ; Chinese University of Hong Kong[2008.1.079] ; One-off Funding for Joint Lab/Research Collaboration from CUHK[00000000] ; Seed Fund for Joint Establishments from CUHK School of Biomedical Science, CUHK[00000000]
WOS关键词	GLYKOSIDE UND AGLYKONE ; MULTIDRUG-RESISTANCE ; PREGNANE GLYCOSIDES ; PERIPLOCA-SEPIUM ; DIE GLYKOSIDE ; CANCER CELLS ; OLIGOSACCHARIDES ; STEMS ; OVEREXPRESSION ; CYTOTOXICITY
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000375166600006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276032]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Lin, Ge; Ye, Yang
作者单位	1.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Chem, State Key Lab Drug Res & Nat Prod, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Beijing 100864, Peoples R China; 4.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Univ Hong Kong, Fac Med, Sch Pharm, Hong Kong, Hong Kong, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yao, Sheng,To, Kenneth Kin-Wah,Ma, Liang,et al. Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity[J]. PHYTOCHEMISTRY,2016,126:47-58.
APA	Yao, Sheng.,To, Kenneth Kin-Wah.,Ma, Liang.,Yin, Chun.,Tang, Chunping.,...&Ye, Yang.(2016).Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.PHYTOCHEMISTRY,126,47-58.
MLA	Yao, Sheng,et al."Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity".PHYTOCHEMISTRY 126(2016):47-58.