Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer

doi:10.1002/adfm.201603381

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	Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer
	Su, Jinghan 1,2,3; Sun, Huiping 1,2,4; Meng, Qingshuo 1,2,3; Yin, Qi1,2 ; Zhang, Pengcheng1,2 ; Zhang, Zhiwen1,2 ; Yu, Haijun1,2 ; Li, Yaping1,2
刊名	ADVANCED FUNCTIONAL MATERIALS
	2016-11-02
卷号	26 期号:41 页码:7495-7506
ISSN号	1616-301X
DOI	10.1002/adfm.201603381
文献子类	Article
英文摘要	Optimal nanosized drug delivery systems (NDDS) require long blood circulation and controlled drug release at target lesions for efficient anticancer therapy. Red blood cell (RBC) membrane-camouflaged nanoparticles (NPs) can integrate flexibility of synergetic materials and highly functionality of RBC membrane, endowed with many unique advantages for drug delivery. Here, new near-infrared (NIR)-responsive RBC membrane-mimetic NPs with NIR-activated cellular uptake and controlled drug release for treating metastatic breast cancer are reported. An NIR dye is inserted in RBC membrane shells, and the thermoresponsive lipid is employed to the paclitaxel (PTX)-loaded polymeric cores to fabricate the RBC-inspired NPs. The fluorescence of dye in the NPs can be used for in vivo tumor imaging with an elongated circulating halftime that is 12.3-folder higher than that of the free dye. Under the NIR laser stimuli, the tumor cellular uptake of NPs is significantly enhanced to 2.1-fold higher than that without irradiation. The structure of the RBC-mimetic NPs can be destroyed by the light-induced hyperthermia, triggered rapid PTX release (45% in 30 min). These RBC-mimetic NPs provide a synergetic chemophotothermal therapy, completely inhibited the growth of the primary tumor, and suppress over 98% of lung metastasis in vivo, suggesting it to be an ideal NDDS to fight against metastatic breast cancer.
资助项目	National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81270047] ; Shanghai Pujiang Program[15PJ1409900]
WOS关键词	ERYTHROCYTE-MEMBRANE ; CELL MEMBRANE ; POLYMERIC NANOPARTICLES ; TUMOR PENETRATION ; DELIVERY ; MICELLES ; PLATFORM ; CHEMOTHERAPY ; COMBINATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000387545500014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275819]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Su, Jinghan,Sun, Huiping,Meng, Qingshuo,et al. Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(41):7495-7506.
APA	Su, Jinghan.,Sun, Huiping.,Meng, Qingshuo.,Yin, Qi.,Zhang, Pengcheng.,...&Li, Yaping.(2016).Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,26(41),7495-7506.
MLA	Su, Jinghan,et al."Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 26.41(2016):7495-7506.