Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration

doi:10.7150/jca.19278

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	Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration
	Zhang, Dadong 1,3; Wu, Heming 2; Zhang, Xiaomin 2; Ding, Xu 2; Huang, Min1,3 ; Geng, Meiyu1,3 ; Li, Hongwei 2; Xie, Zuoquan1,3
刊名	JOURNAL OF CANCER
	2017
卷号	8 期号:11 页码:1943-1951
关键词	Oral cancer Phosphoglycerate mutase 1 Migration Prognosis SRC
ISSN号	1837-9664
DOI	10.7150/jca.19278
文献子类	Article
英文摘要	Oral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastatic potential. However, no good biomarker has been identified to refine which subtype is of high metastatic potential to make decisions regarding the elective and therapeutic management of lymphatic metastases. In this study, we investigated the role of the metabolic enzyme phosphoglycerate mutase 1 (PGAM1) in OSCC. PGAM1 expression was examined in tissue samples of 122 OSCC patients using immunohistochemistry, and the correlation between clinicopathological expression and PGAM1 expression was determined. Survival curves were generated using the Kaplan-Meier method, and multivariate analysis was performed by the Cox proportional hazards model. Moreover, PGAM1 was knocked down in the OSCC cell lines Cal27 and HN12, followed by determination of the change in cell migration and signaling pathways. PGAM1 expression is correlated with age, lymphatic metastasis and tumor recurrence and is closely associated with poor overall survival (OS) and disease-free survival (DFS). Intriguingly, PGAM1 is an independent risk factor for OS and DFS. After knocking down PGAM1 in Cal27 and HN12 cells, cell migration was remarkably decreased along with signaling pathway molecules, such as proto-oncogene c-SRC (SRC), Focal adhesion kinase (FAK) and Paxillin. The effect on cell migration was abolished following pretreatment with an SRC inhibitor. This study suggested that PGAM1 is a poor prognostic biomarker of OSCC and may be used to select patients of high metastatic potential in the clinic, and PGAM1 promotes the migration of OSCC cells is associated with the SRC pathway.
资助项目	National Natural Science Foundation of China[81202549] ; "Personalized Medicines-- Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020341]
WOS关键词	PYRUVATE-KINASE M2 ; CANCER ; LUNG ; DISCOVERY ; GROWTH
WOS研究方向	Oncology
语种	英语
出版者	IVYSPRING INT PUBL
WOS记录号	WOS:000406938500002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275704]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Hongwei; Xie, Zuoquan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Anti Tumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Nanjing Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp Stomatol, Jiangsu Key Lab Oral Dis, Nanjing 210029, Jiangsu, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dadong,Wu, Heming,Zhang, Xiaomin,et al. Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration[J]. JOURNAL OF CANCER,2017,8(11):1943-1951.
APA	Zhang, Dadong.,Wu, Heming.,Zhang, Xiaomin.,Ding, Xu.,Huang, Min.,...&Xie, Zuoquan.(2017).Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration.JOURNAL OF CANCER,8(11),1943-1951.
MLA	Zhang, Dadong,et al."Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration".JOURNAL OF CANCER 8.11(2017):1943-1951.