Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage

doi:10.1021/acs.orglett.6b03597

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	Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage
	Huang, Xing-Hao 1,2,4; Tao, Ling-Xue 3; Ke, Chang-Qiang1,2 ; Tang, Chunping1,2 ; Zhang, Hai-Yan3 ; Ye, Yang1,2,5 ; Lin, Li-Gen 6; Yao, Sheng1,2
刊名	ORGANIC LETTERS
	2017-02-03
卷号	19 期号:3 页码:556-559
ISSN号	1523-7060
DOI	10.1021/acs.orglett.6b03597
文献子类	Article
英文摘要	Two dimeric diterpenoids, taxodikaloids A (1) and B (2), have been identified from the seeds of Taxodium ascendens. The diterpenoid structures were established on the basis of comprehensive spectroscopic analysis, and the absolute configuration of taxodikaloid A (1) was further confirmed by single-crystal X-ray diffraction. Both structures feature an unprecedented oxazoline ring linkage connecting two abietane diterpenoid monomers. A plausible biosynthetic pathway for compounds 1 and 2 is proposed. Both compounds show potential neuroprotective activity against A beta(25-35)-induced damage in SH-SY5Y cells.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Foundation of China[81302657] ; National Natural Science Foundation of China[81473112] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; State Key Laboratory of Drug Research[SIMM1501ZZ-03] ; Science and Technology Development Fund of Macau[FCDT 120/2013/A3] ; Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Research Fund of University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS关键词	TAIWANIA CRYPTOMERIOIDES ; ALZHEIMERS-DISEASE ; SH-SY5Y CELLS ; FORMOSANA ; BARK ; CYCLOADDUCTS ; HEARTWOOD ; JAPONICA ; INJURY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000393539900033
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275637]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Lin, Li-Gen; Yao, Sheng
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China; 6.Univ Macau, Inst Chinese Med Sci, Key Lab Qual Res Chinese Med, Macau, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xing-Hao,Tao, Ling-Xue,Ke, Chang-Qiang,et al. Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage[J]. ORGANIC LETTERS,2017,19(3):556-559.
APA	Huang, Xing-Hao.,Tao, Ling-Xue.,Ke, Chang-Qiang.,Tang, Chunping.,Zhang, Hai-Yan.,...&Yao, Sheng.(2017).Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage.ORGANIC LETTERS,19(3),556-559.
MLA	Huang, Xing-Hao,et al."Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage".ORGANIC LETTERS 19.3(2017):556-559.